{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:30:50Z","timestamp":1790973050158,"version":"4.1.0"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6462","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,10,11]]},"abstract":"<jats:title>\n            Fine control of brain GABA\n            <jats:sub>A<\/jats:sub>\n            receptors\n          <\/jats:title>\n          <jats:p>\n            GABA\n            <jats:sub>A<\/jats:sub>\n            (\u03b3-aminobutyric acid type A) receptors are ligand-gated anion channels that mediate fast inhibitory transmission in the mammalian brain. Han\n            <jats:italic>et al.<\/jats:italic>\n            investigated if a protein called SHISA7 was involved in regulating GABA\n            <jats:sub>A<\/jats:sub>\n            receptor expression and function (see the Perspective by Rudolph and Moss). SHISA7 was found at GABA-releasing synapses, where it interacted with GABA\n            <jats:sub>A<\/jats:sub>\n            receptors, controlled receptor concentration at the synapse, sped up receptor deactivation kinetics, and modulated some behavioral properties of benzodiazepines. SHISA7 thus affects surface expression, gating kinetics, and pharmacology of GABA\n            <jats:sub>A<\/jats:sub>\n            receptors in the brain.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6462\" page=\"246\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aax5719\">246<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6462\" page=\"185\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aaz3176\">185<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aax5719","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T21:32:07Z","timestamp":1571175127000},"page":"246-250","source":"Crossref","is-referenced-by-count":99,"title":["Shisa7 is a GABA\n            <sub>A<\/sub>\n            receptor auxiliary subunit controlling benzodiazepine actions"],"prefix":"10.1126","volume":"366","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-1430","authenticated-orcid":true,"given":"Wenyan","family":"Han","sequence":"first","affiliation":[{"name":"Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1044-3724","authenticated-orcid":true,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-1336","authenticated-orcid":true,"given":"Kenneth A.","family":"Pelkey","sequence":"additional","affiliation":[{"name":"Cellular and Synaptic Neuroscience Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2340-4975","authenticated-orcid":true,"given":"Saurabh","family":"Pandey","sequence":"additional","affiliation":[{"name":"Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-6705","authenticated-orcid":true,"given":"Xiumin","family":"Chen","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4074-0567","authenticated-orcid":true,"given":"Kunwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-446X","authenticated-orcid":true,"given":"Lihao","family":"Ge","sequence":"additional","affiliation":[{"name":"Synaptic Transmission Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-8632","authenticated-orcid":true,"given":"Tianming","family":"Li","sequence":"additional","affiliation":[{"name":"Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-3720","authenticated-orcid":true,"given":"David","family":"Castellano","sequence":"additional","affiliation":[{"name":"Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-9225","authenticated-orcid":true,"given":"Chengyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Transgenetic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Synaptic Transmission Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald S.","family":"Petralia","sequence":"additional","affiliation":[{"name":"Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-2252","authenticated-orcid":true,"given":"Joseph W.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-0157","authenticated-orcid":true,"given":"Chris J.","family":"McBain","sequence":"additional","affiliation":[{"name":"Cellular and Synaptic Neuroscience Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-8432","authenticated-orcid":true,"given":"Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.386664"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.108.00505"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2370"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.03.024"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2010"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1625"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2014.11.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2014.10.002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014449"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.04.003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10682"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1184178"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00007.2017"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.724443"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039572"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.023"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.09.025"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.015"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.12.038"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3670"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/44579"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/75761"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5489.131"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/80553"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.10.001"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09693"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24192"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05574.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5012-10.2011"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/81800"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199803000-00030"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00188"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00174-0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.042960"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1496"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.04.007"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.03.001"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.09.005"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.04.009"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00402"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10873"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209881110"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav7969"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00462.2010"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.171"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(91)90154-R"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703259"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.044834"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.01.001"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00803-5"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28674"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq023"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-012-1456-y"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.514695"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.017"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1534"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.01.022"},{"key":"e_1_3_2_59_2","first-page":"73","article-title":"Immunocytochemistry of NMDA receptors","volume":"128","author":"Petralia R. S.","year":"1999","unstructured":"R. S. Petralia, R. J. Wenthold, Immunocytochemistry of NMDA receptors. Methods Mol. Biol. 128, 73\u201392 (1999). 10320974","journal-title":"Methods Mol. Biol."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3365"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36263-w"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2372"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.108"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aax5719","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aax5719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:25:28Z","timestamp":1705364728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aax5719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":62,"journal-issue":{"issue":"6462","published-print":{"date-parts":[[2019,10,11]]}},"alternative-id":["10.1126\/science.aax5719"],"URL":"https:\/\/doi.org\/10.1126\/science.aax5719","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,11]]}}}