{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:34:15Z","timestamp":1792647255212,"version":"4.5.0"},"reference-count":81,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6468","funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_156818, 310030_182315"],"award-info":[{"award-number":["310030_156818, 310030_182315"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,11,22]]},"abstract":"<jats:title>\n            Magnesium for\n            <jats:italic>Salmonella<\/jats:italic>\n            growth\n          <\/jats:title>\n          <jats:p>\n            In mammals, macrophages are a first line of defense against pathogenic bacteria like\n            <jats:italic>Salmonella.<\/jats:italic>\n            These immune cells possess a metal-ion transporter called SLC11A1 or NRAMP1, which is known to be involved in infection resistance. Cunrath and Bumann studied mice that only differ in one allele of the\n            <jats:italic>SLC11A1<\/jats:italic>\n            gene, which leaves mice either susceptible or resistant to infection. Proteomic analyses showed that bacteria isolated from mice with functional\n            <jats:italic>SLC11A1<\/jats:italic>\n            alleles experienced metal starvation, particularly of magnesium. The resulting impairment of bacterial growth seems to be the primary mode of action of SLC11A1 against invading pathogens.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6468\" page=\"995\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aax7898\">995<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aax7898","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:40:51Z","timestamp":1574728851000},"page":"995-999","source":"Crossref","is-referenced-by-count":169,"title":["Host resistance factor SLC11A1 restricts\n            <i>Salmonella<\/i>\n            growth through magnesium deprivation"],"prefix":"10.1126","volume":"366","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9930-0748","authenticated-orcid":true,"given":"Olivier","family":"Cunrath","sequence":"first","affiliation":[{"name":"Biozentrum, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3636-4239","authenticated-orcid":true,"given":"Dirk","family":"Bumann","sequence":"additional","affiliation":[{"name":"Biozentrum, University of Basel, CH-4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.643973"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111763"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.045"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.4049\/jimmunol.144.8.3143","article-title":"The primary effect of the Ity locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing","volume":"144","author":"Benjamin W. 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