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Siciliano\n                    <jats:italic>et al.<\/jats:italic>\n                    first established a behavioral measure to assess how predisposition interacts with experience to produce compulsive drinking in a subset of mice (see the Perspective by Nixon and Mangieri). In search of the underlying neurobiological mechanism, they discovered that a discrete circuit between the medial prefrontal cortex and brainstem is central for the development of compulsive drinking. This circuit serves as both a biomarker for the development of compulsive drinking and a driver of its expression. It can bidirectionally control compulsive behavior by mitigating or mimicking punishment signals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6468\" page=\"1008\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aay1186\">1008<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6468\" page=\"947\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aaz7357\">947<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aay1186","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T19:40:51Z","timestamp":1574710851000},"page":"1008-1012","source":"Crossref","is-referenced-by-count":208,"title":["A cortical-brainstem circuit predicts and governs compulsive alcohol drinking"],"prefix":"10.1126","volume":"366","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-2089","authenticated-orcid":true,"given":"Cody A.","family":"Siciliano","sequence":"first","affiliation":[{"name":"The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA."},{"name":"Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, TN 37232, 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