{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:56:17Z","timestamp":1791921377856,"version":"4.3.4"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6474","funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["681819"],"award-info":[{"award-number":["681819"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001658","name":"Minerva Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["492\/15"],"award-info":[{"award-number":["492\/15"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,1,10]]},"abstract":"<jats:title>Challenges of drug combinations<\/jats:title>\n                  <jats:p>\n                    Combinations of antibiotics are used to treat intractable infections such as methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . Clinically, however, drugs tend to be used empirically, and results can be contradictory. Liu\n                    <jats:italic>et al.<\/jats:italic>\n                    translated observations made in vitro to patient samples to understand the role of antibiotic tolerance in promoting or suppressing resistance when drug combinations are used (see the Perspective by Berti and Hirsch). Although bacterial populations exposed to multiple antibiotics can develop tolerance to multiple drugs, one drug in a combination may be able counter resistance to a partner drug and provide effective therapy. However, if tolerance has already emerged to one drug, the combination may end up promoting the transmission of resistance to a partner drug.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6474\" page=\"200\" related-article-type=\"in-this-issue\" vol=\"367\" xlink:href=\"10.1126\/science.aay3041\">200<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6474\" page=\"141\" related-article-type=\"in-this-issue\" vol=\"367\" xlink:href=\"10.1126\/science.aba0150\">141<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aay3041","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T23:55:17Z","timestamp":1613260517000},"page":"200-204","source":"Crossref","is-referenced-by-count":495,"title":["Effect of tolerance on the evolution of antibiotic resistance under drug combinations"],"prefix":"10.1126","volume":"367","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3301-7194","authenticated-orcid":true,"given":"Jiafeng","family":"Liu","sequence":"first","affiliation":[{"name":"Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-4731","authenticated-orcid":true,"given":"Orit","family":"Gefen","sequence":"additional","affiliation":[{"name":"Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irine","family":"Ronin","sequence":"additional","affiliation":[{"name":"Racah Institute of Physics, Edmond J. 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