{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:09:15Z","timestamp":1791979755885,"version":"4.4.0"},"reference-count":72,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6480","funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALT 490-2017"],"award-info":[{"award-number":["ALT 490-2017"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["WT211276\/Z\/18\/Z"],"award-info":[{"award-number":["WT211276\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["WT206194"],"award-info":[{"award-number":["WT206194"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["WT107931\/Z\/15\/Z"],"award-info":[{"award-number":["WT107931\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R006237\/1"],"award-info":[{"award-number":["MR\/R006237\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["646794"],"award-info":[{"award-number":["646794"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["G053816N"],"award-info":[{"award-number":["G053816N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ghent University","award":["BOF18-GOA-024"],"award-info":[{"award-number":["BOF18-GOA-024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,2,21]]},"abstract":"<jats:title>Thymus development, cell by cell<\/jats:title>\n                  <jats:p>\n                    The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection. However, it is not well known how these cells develop with a full immune complement that contains the necessary variation to protect us from a variety of pathogens. By performing single-cell RNA sequencing on more than 250,000 cells, Park\n                    <jats:italic>et al.<\/jats:italic>\n                    examined the changes that occur in the thymus over the course of a human life. They found that development occurs in a coordinated manner among immune cells and with their developmental microenvironment. These data allowed for the creation of models of how T cells with different specific immune functions develop in humans.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aay3224\">eaay3224<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aay3224","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T19:05:20Z","timestamp":1582225520000},"source":"Crossref","is-referenced-by-count":666,"title":["A cell atlas of human thymic development defines T cell repertoire formation"],"prefix":"10.1126","volume":"367","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1687-2423","authenticated-orcid":true,"given":"Jong-Eun","family":"Park","sequence":"first","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-4605","authenticated-orcid":true,"given":"Rachel A.","family":"Botting","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8684-4655","authenticated-orcid":true,"given":"Cecilia","family":"Dom\u00ednguez Conde","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorin-Mirel","family":"Popescu","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5814-7940","authenticated-orcid":true,"given":"Marieke","family":"Lavaert","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium."},{"name":"Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3597-6591","authenticated-orcid":true,"given":"Daniel J.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."},{"name":"Theory of Condensed Matter Group, Cavendish Laboratory\/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK."},{"name":"Wellcome Trust\/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6397-3518","authenticated-orcid":true,"given":"Issac","family":"Goh","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4244-4019","authenticated-orcid":true,"given":"Emily","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ragazzini","sequence":"additional","affiliation":[{"name":"Epithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK."},{"name":"Great Ormond Street Institute of Child Health, University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-7549","authenticated-orcid":true,"given":"Elizabeth","family":"Tuck","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wilbrey-Clark","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-0821","authenticated-orcid":true,"given":"Kenny","family":"Roberts","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-0829","authenticated-orcid":true,"given":"Veronika R.","family":"Kedlian","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0936-0128","authenticated-orcid":true,"given":"John R.","family":"Ferdinand","sequence":"additional","affiliation":[{"name":"Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"He","sequence":"additional","affiliation":[{"name":"John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3058-8952","authenticated-orcid":true,"given":"Simone","family":"Webb","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Maunder","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6582-0040","authenticated-orcid":true,"given":"Niels","family":"Vandamme","sequence":"additional","affiliation":[{"name":"Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-2334","authenticated-orcid":true,"given":"Krishnaa T.","family":"Mahbubani","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-9576","authenticated-orcid":true,"given":"Krzysztof","family":"Polanski","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-8622","authenticated-orcid":true,"given":"Lira","family":"Mamanova","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-0774","authenticated-orcid":true,"given":"Liam","family":"Bolt","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Crossland","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."},{"name":"Department of Adult Congenital Heart Disease and Paediatric Cardiology\/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-4644","authenticated-orcid":true,"given":"Fabrizio","family":"de Rita","sequence":"additional","affiliation":[{"name":"Department of Adult Congenital Heart Disease and Paediatric Cardiology\/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Fuller","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Filby","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-8708","authenticated-orcid":true,"given":"Gary","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-1801","authenticated-orcid":true,"given":"David","family":"Dixon","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-3696","authenticated-orcid":true,"given":"Kourosh","family":"Saeb-Parsy","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-3971","authenticated-orcid":true,"given":"Steven","family":"Lisgo","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2705-5998","authenticated-orcid":true,"given":"Deborah","family":"Henderson","sequence":"additional","affiliation":[{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9870-8474","authenticated-orcid":true,"given":"Roser","family":"Vento-Tormo","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer A.","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-7730","authenticated-orcid":true,"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[{"name":"John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK."},{"name":"WT-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre Cambridge Biomedical Campus, Cambridge CB2 0AW, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-1498","authenticated-orcid":true,"given":"Kerstin B.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0415-1506","authenticated-orcid":true,"given":"Yvan","family":"Saeys","sequence":"additional","affiliation":[{"name":"Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"Epithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK."},{"name":"Great Ormond Street Institute of Child Health, University College London, London, UK."},{"name":"Institute of Immunity and Transplantation, University College London, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6600-7665","authenticated-orcid":true,"given":"Sam","family":"Behjati","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."},{"name":"Department of Paediatrics, University of Cambridge, Cambridge CB2 0SP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-9828","authenticated-orcid":true,"given":"Menna R.","family":"Clatworthy","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."},{"name":"Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK."},{"name":"Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5781-0288","authenticated-orcid":true,"given":"Tom","family":"Taghon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium."},{"name":"Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-2084","authenticated-orcid":true,"given":"Muzlifah","family":"Haniffa","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."},{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK."},{"name":"Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-6366","authenticated-orcid":true,"given":"Sarah A.","family":"Teichmann","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK."},{"name":"Theory of Condensed Matter Group, Cavendish Laboratory\/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714478115"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.04.003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075035"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.1.19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep14871"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2005.05.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.03.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.03.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4161\/cam.4.3.11789"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-023143"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.01.011"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2993"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.059998"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.015"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0346-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0345-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2731"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.087320"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.007"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1292"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.4049\/jimmunol.151.11.6110","article-title":"Few V gene segments dominate the T cell receptor \u03b2-chain repertoire of the human thymus","volume":"151","author":"Jores R.","year":"1993","unstructured":"R. Jores, T. Meo, Few V gene segments dominate the T cell receptor \u03b2-chain repertoire of the human thymus. J. Immunol. 151, 6110\u20136122 (1993). 8245454","journal-title":"J. Immunol."},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","unstructured":"J. A. Carter J. B. Preall K. Grigaityte S. J. Goldfless A. W. Briggs F. Vigneault G. S. Atwal T cell receptor \u03b1\u03b2 chain pairing is associated with CD4 + and CD8 + lineage specification. bioRxiv 293852 [preprint]. 3 April 2018.","DOI":"10.1101\/293852"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140815"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.115428.110"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304048110"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz625"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002185"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200358"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.02.003"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.4668"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2003.11.013"},{"key":"e_1_3_2_33_2","first-page":"253","article-title":"Myoid cells and neuroendocrine markers in myasthenic thymuses","volume":"46","author":"Z\u00f3\u0142towska A.","year":"1998","unstructured":"A. Z\u00f3\u0142towska, T. Pawe\u0142czyk, M. Stopa, J. Skokowski, J. Stepi\u0144ski, A. Roszkiewicz, W. Nyka, Myoid cells and neuroendocrine markers in myasthenic thymuses. Arch. Immunol. Ther. Exp. 46, 253\u2013257 (1998). 9779292","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan8664"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00365"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0698-6"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.02.005"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062497"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1954"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.165597"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201815"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171000"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-290049"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121798"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1652-y"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.008"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10291-0"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302259"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.3094"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1549"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042524"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.022"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0289-6"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aah4232"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2011.00036"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.12.016"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3751"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.4110\/in.2015.15.3.111"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4573"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03886"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.3109\/08830189009056629"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02902"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00398"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102327"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1448"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504971112"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.045"},{"key":"e_1_3_2_68_2","unstructured":"P. Bullen D. I. Wilson in Molecular Genetics of Early Human Development T. Strachan S. Lindsay D. I. Wilson Eds. (BIOS 1997) pp. 27\u201335."},{"key":"e_1_3_2_69_2","first-page":"26","article-title":"Correlation of fetal age and measurements between 10 and 26 weeks of gestation","volume":"63","author":"Hern W. M.","year":"1984","unstructured":"W. M. Hern, Correlation of fetal age and measurements between 10 and 26 weeks of gestation. Obstet. Gynecol. 63, 26\u201332 (1984). 6691014","journal-title":"Obstet. Gynecol."},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2018.11.005"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3971"},{"key":"e_1_3_2_72_2","doi-asserted-by":"crossref","unstructured":"J.-E. Park K. Pola\u0144ski K. Meyer S. A. Teichmann Fast Batch Alignment of Single Cell Transcriptomes Unifies Multiple Mouse Cell Atlases into an Integrated Landscape. bioRxiv 397042 [preprint]. 22 August 2018.","DOI":"10.1101\/397042"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky822"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.aay3224","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aay3224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T18:33:01Z","timestamp":1705343581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aay3224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,21]]},"references-count":72,"journal-issue":{"issue":"6480","published-print":{"date-parts":[[2020,2,21]]}},"alternative-id":["10.1126\/science.aay3224"],"URL":"https:\/\/doi.org\/10.1126\/science.aay3224","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737403297.793573413","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.737403297.793571706","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.28.911115","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,21]]},"article-number":"eaay3224"}}