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Current treatments can cause systemic immune suppression and side effects such as increased risk of infections. Krienke\n                    <jats:italic>et al.<\/jats:italic>\n                    designed a messenger RNA vaccine strategy that lacks adjuvant activity and delivers MS autoantigens into lymphoid dendritic cells. This approach expands a distinct type of antigen-specific effector regulatory T cell that suppresses autoreactivity against targeted autoantigens and promotes bystander suppression of autoreactive T cells against other myelin-specific autoantigens. In mouse models of MS, the vaccine delayed the onset and reduced the severity of established disease without showing overt symptoms of general immune suppression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6525\" page=\"145\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.aay3638\">145<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aay3638","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T15:31:44Z","timestamp":1610033504000},"page":"145-153","source":"Crossref","is-referenced-by-count":501,"title":["A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis"],"prefix":"10.1126","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-7191","authenticated-orcid":true,"given":"Christina","family":"Krienke","sequence":"first","affiliation":[{"name":"TRON \u2013 Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany."},{"name":"Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University, Langenbeckstr. 1, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-3567","authenticated-orcid":true,"given":"Laura","family":"Kolb","sequence":"additional","affiliation":[{"name":"TRON \u2013 Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5300-7172","authenticated-orcid":true,"given":"Elif","family":"Diken","sequence":"additional","affiliation":[{"name":"TRON \u2013 Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-938X","authenticated-orcid":true,"given":"Michael","family":"Streuber","sequence":"additional","affiliation":[{"name":"TRON \u2013 Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0959-3338","authenticated-orcid":true,"given":"Sarah","family":"Kirchhoff","sequence":"additional","affiliation":[{"name":"TRON \u2013 Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9020-8857","authenticated-orcid":true,"given":"Thomas","family":"Bukur","sequence":"additional","affiliation":[{"name":"TRON \u2013 Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Akilli-\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"TRON \u2013 Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1943-3431","authenticated-orcid":true,"given":"Lena M.","family":"Kranz","sequence":"additional","affiliation":[{"name":"Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Berger","sequence":"additional","affiliation":[{"name":"Biopharmaceutical New Technologies (BioNTech) Corporation, An der Goldgrube 12, Mainz 55131, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-6842","authenticated-orcid":true,"given":"Jutta","family":"Petschenka","sequence":"additional","affiliation":[{"name":"TRON \u2013 Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany."},{"name":"Cancer Immunology and Immune Modulation, Boehringer Ingelheim Pharma GmbH &amp; Co. 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