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Although other actin-regulatory proteins modulate human immune responses, the precise role for the WRC has not yet been established. Cook\n                    <jats:italic>et al.<\/jats:italic>\n                    studied five patients from four unrelated families who harbor missense variants of the gene encoding the WRC component HEM1. These patients presented with recurrent infections and poor antibody responses, along with enhanced allergic and autoimmune disorders. HEM1 was found to be required for the regulation of cortical actin and granule release in T cells and also interacted with a key metabolic signaling complex contributing to the disease phenotype. By linking these interactions to immune function, this work suggests potential targets for future immunotherapies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6500\" page=\"202\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.aay5663\">202<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aay5663","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T19:10:02Z","timestamp":1594321802000},"page":"202-207","source":"Crossref","is-referenced-by-count":105,"title":["HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-4009","authenticated-orcid":true,"given":"Sarah A.","family":"Cook","sequence":"first","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1173-1127","authenticated-orcid":true,"given":"William A.","family":"Comrie","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."},{"name":"Neomics Pharmaceuticals, LLC, Gaithersburg, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6817-0573","authenticated-orcid":true,"given":"M. Cecilia","family":"Poli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA."},{"name":"Section of Pediatric Immunology, Allergy, and Retrovirology, Texas Children\u2019s Hospital, Houston, TX, USA."},{"name":"Program of Immunogenetics and Translational Immunology, Instituto de Ciencias e Innovaci\u00f3n en Medicina, Facultad de Medicina, Cl\u00ednica Alemana\u2013Universidad del Desarrollo, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0403-2689","authenticated-orcid":true,"given":"Morgan","family":"Similuk","sequence":"additional","affiliation":[{"name":"Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6310-0434","authenticated-orcid":true,"given":"Andrew J.","family":"Oler","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-3767","authenticated-orcid":true,"given":"Aiman J.","family":"Faruqi","sequence":"additional","affiliation":[{"name":"Molecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-0760","authenticated-orcid":true,"given":"Douglas B.","family":"Kuhns","sequence":"additional","affiliation":[{"name":"Neutrophil Monitoring Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-3728","authenticated-orcid":true,"given":"Sheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Vargas-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA."},{"name":"Section of Pediatric Immunology, Allergy, and Retrovirology, Texas Children\u2019s Hospital, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-2205","authenticated-orcid":true,"given":"Alexandre F.","family":"Carisey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA."},{"name":"Section of Pediatric Immunology, Allergy, and Retrovirology, Texas Children\u2019s Hospital, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4189-996X","authenticated-orcid":true,"given":"Benjamin","family":"Fournier","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Activation and Susceptibility to EBV, INSERM UMR 1163, Paris, France."},{"name":"University Paris Descartes Sorbonne Paris Cit\u00e9, Institut des Maladies G\u00e9n\u00e9tiques-IMAGINE, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-0201","authenticated-orcid":true,"given":"D. 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