{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:57:28Z","timestamp":1792699048933,"version":"4.5.0"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6465","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI095981"],"award-info":[{"award-number":["R21AI095981"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI131228"],"award-info":[{"award-number":["R01 AI131228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24AI118633"],"award-info":[{"award-number":["U24AI118633"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK032493"],"award-info":[{"award-number":["R01 DK032493"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>The toll of measles on the immune system<\/jats:title>\n                  <jats:p>\n                    Many of the deaths attributable to measles virus are caused by secondary infections because the virus infects and functionally impairs immune cells. Whether measles infection causes long-term damage to immune memory has been unclear. This question has become increasingly important given the resurgence in measles epidemics worldwide. Using a blood test called VirScan, Mina\n                    <jats:italic>et al.<\/jats:italic>\n                    comprehensively analyzed the antibody repertoire in children before and after natural infection with measles virus as well as in children before and after measles vaccination. They found that measles infection can greatly diminish previously acquired immune memory, potentially leaving individuals at risk for infection by other pathogens. These adverse effects on the immune system were not seen in vaccinated children.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6465\" page=\"599\" related-article-type=\"in-this-issue\" vol=\"366\" xlink:href=\"10.1126\/science.aay6485\">599<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aay6485","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T19:10:03Z","timestamp":1572549003000},"page":"599-606","source":"Crossref","is-referenced-by-count":461,"title":["Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens"],"prefix":"10.1126","volume":"366","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0674-5762","authenticated-orcid":true,"given":"Michael J.","family":"Mina","sequence":"first","affiliation":[{"name":"Division of Genetics, Brigham and Women\u2019s Hospital, Howard Hughes Medical Institute, Boston,\u00a0MA\u00a002115, USA."},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."},{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-9833","authenticated-orcid":true,"given":"Tomasz","family":"Kula","sequence":"additional","affiliation":[{"name":"Division of Genetics, Brigham and Women\u2019s Hospital, Howard Hughes Medical Institute, Boston,\u00a0MA\u00a002115, USA."},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-9284","authenticated-orcid":true,"given":"Yumei","family":"Leng","sequence":"additional","affiliation":[{"name":"Division of Genetics, Brigham and Women\u2019s Hospital, Howard Hughes Medical Institute, Boston,\u00a0MA\u00a002115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory D.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam, 3015 CN, Rotterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-0033","authenticated-orcid":true,"given":"Mikael","family":"Knip","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland."},{"name":"Research Program for Clinical and Molecular Metabolism, University of Helsinki, 00014 Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-2822","authenticated-orcid":true,"given":"Heli","family":"Siljander","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland."},{"name":"Research Program for Clinical and Molecular Metabolism, University of Helsinki, 00014 Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-9207","authenticated-orcid":true,"given":"Marian","family":"Rewers","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Denver, CO 80045, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Choy","sequence":"additional","affiliation":[{"name":"Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-1281","authenticated-orcid":true,"given":"Mark S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Genentech Inc., South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Benjamin","family":"Larman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4647-7667","authenticated-orcid":true,"given":"Ashley N.","family":"Nelson","sequence":"additional","affiliation":[{"name":"W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-2429","authenticated-orcid":true,"given":"Diane E.","family":"Griffin","sequence":"additional","affiliation":[{"name":"W. 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