{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:49:43Z","timestamp":1792165783963,"version":"4.4.0"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6502","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI114618"],"award-info":[{"award-number":["R01AI114618"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI055472"],"award-info":[{"award-number":["R01AI055472"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,7,24]]},"abstract":"<jats:title>Rab32 puts itaconate where it's needed<\/jats:title>\n                  <jats:p>\n                    Myeloid cells can restrict the replication of intracellular bacterial pathogens such as\n                    <jats:italic>Salmonella<\/jats:italic>\n                    using a Rab family guanosine triphosphatase called Rab32. However, the underlying mechanisms remain unclear. Chen\n                    <jats:italic>et al.<\/jats:italic>\n                    report that Rab32 and its exchange factor, BLOC3, interact with aconitate decarboxylase 1 (IRG1). This complex enables the direct delivery of IRG1's antimicrobial product, itaconate, from the mitochondria to\n                    <jats:italic>Salmonella<\/jats:italic>\n                    -containing vacuoles. Itaconate concentrations in vacuoles correlated with bacterial survival, highlighting the biological relevance of this metabolite during infections. Similar findings in\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    \u2013infected cells suggest that this is a more general phenomenon in which mitochondria and the Rab32 pathway play a critical role in antibacterial host defense.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6502\" page=\"450\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.aaz1333\">450<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaz1333","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T13:52:19Z","timestamp":1620309139000},"page":"450-455","source":"Crossref","is-referenced-by-count":167,"title":["Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against\n                    <i>Salmonella<\/i>"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-0396","authenticated-orcid":true,"given":"Meixin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-6475","authenticated-orcid":true,"given":"Maikel","family":"Boot","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Jung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-2095","authenticated-orcid":true,"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"WM Keck Foundation Biotechnology Resource Laboratory, Yale University School of Medicine, New Haven, CT 06536, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-3462","authenticated-orcid":true,"given":"Tukiet T.","family":"Lam","sequence":"additional","affiliation":[{"name":"WM Keck Foundation Biotechnology Resource Laboratory, Yale University School of Medicine, New Haven, CT 06536, USA."},{"name":"Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1339-0859","authenticated-orcid":true,"given":"Maria","family":"Lara-Tejero","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2973-8354","authenticated-orcid":true,"given":"E. 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