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The transition from endothelial cells to blood stem cells is highly regulated and restricted to a small portion of endothelial cells during a brief period of time. The mechanisms regulating this transition are also poorly understood. Kasper\n                    <jats:italic>et al.<\/jats:italic>\n                    found that microRNA-223 intrinsically restrains the vascular hematopoietic transition by regulating N-glycan biosynthesis to restrict hematopoietic stem and progenitor cell production and differentiation. Genetics or chemicals could be used to alter the sugar code and change the efficiency of blood production in embryos. Thus, genetically or pharmacologically altering N-glycan biosynthesis in endothelial cells could improve the efficiency of the production of blood stem cells, which could then be used to treat blood diseases such as leukemia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6521\" page=\"1186\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.aaz2121\">1186<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaz2121","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T19:05:39Z","timestamp":1607022339000},"page":"1186-1191","source":"Crossref","is-referenced-by-count":46,"title":["The N-glycome regulates the endothelial-to-hematopoietic transition"],"prefix":"10.1126","volume":"370","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-6680","authenticated-orcid":true,"given":"Dionna M.","family":"Kasper","sequence":"first","affiliation":[{"name":"Yale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA."},{"name":"Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA."},{"name":"Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Hintzen","sequence":"additional","affiliation":[{"name":"Yale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA."},{"name":"Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA."},{"name":"Vascular 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