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Current understanding of this vital tissue in humans is limited. Pellegrini\n                    <jats:italic>et al.<\/jats:italic>\n                    developed choroid plexus organoids that quantitatively predict human brain permeability of small molecules and secrete an isolated CSF-like fluid (see the Perspective by Silva-Vargas and Doetsch). This CSF model reveals secretion of developmental factors and disease-related biomarkers by key cell types and provides a testing ground for drug entry into the brain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aaz5626\">eaaz5626<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6500\" page=\"143\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.abd0269\">143<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaz5626","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T19:09:36Z","timestamp":1591902576000},"source":"Crossref","is-referenced-by-count":475,"title":["Human CNS barrier-forming organoids with cerebrospinal fluid production"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-664X","authenticated-orcid":true,"given":"Laura","family":"Pellegrini","sequence":"first","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4160-1163","authenticated-orcid":true,"given":"Claudia","family":"Bonfio","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Chadwick","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Begum","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-0901","authenticated-orcid":true,"given":"Mark","family":"Skehel","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2324-8853","authenticated-orcid":true,"given":"Madeline A.","family":"Lancaster","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3921"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154026"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.013"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3081-14.2015"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1807-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-8-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1970.33.5.0506"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12517"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22047"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25032"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9896"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.01.027"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3906"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0350-2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3227-12.2012"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01915"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3258-13.2013"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00032"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.64"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","unstructured":"N. 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