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Cholangiocytes are epithelial cells that line bile ducts and modify bile as its transported through the biliary tree. Chronic liver diseases involving cholangiocytes account for a large fraction of liver failure and the need for liver transplantation. Because liver donors are in short supply, Sampaziotis\n                    <jats:italic>et al.<\/jats:italic>\n                    used organoid technology to develop a cell-based therapy using human tissue (see the Perspective by Kurial and Willenbring). Cholangiocyte organoids were transplanted into the intrahepatic ducts of deceased human donor livers undergoing ex vivo normothermic perfusion. The livers could be maintained for up to 100 hours, and the transplanted organoids engrafted, exhibited function, and could repair bile ducts.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6531\" page=\"839\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.aaz6964\">839<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6531\" page=\"786\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.abg3179\">786<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aaz6964","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T13:51:42Z","timestamp":1613742702000},"page":"839-846","source":"Crossref","is-referenced-by-count":384,"title":["Cholangiocyte organoids can repair bile ducts after transplantation in the human liver"],"prefix":"10.1126","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0812-7586","authenticated-orcid":true,"given":"Fotios","family":"Sampaziotis","sequence":"first","affiliation":[{"name":"Wellcome\u2013MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK."},{"name":"Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK."},{"name":"Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, 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