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Children diagnosed with Menkes present with connective tissue abnormalities and neurodegenerative changes that result in death caused by severe copper deficiency, typically before 3 years of age. In the brain, lack of copper impairs cytochrome c oxidase (complex IV) in the electron transport chain, which leads to progressive neurological injury in Menkes patients. No treatment exists for Menkes disease because of the difficulty in supplying the brain with copper using traditional hydrophilic copper complexes such as copper histidine. Guthrie\n            <jats:italic>et al.<\/jats:italic>\n            developed a treatment involving the drug elesclomol that successfully alleviated disease symptoms in a mouse model of Menkes disease (see the Perspective by Lutsenko).\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6491\" page=\"620\" related-article-type=\"in-this-issue\" vol=\"368\" xlink:href=\"10.1126\/science.aaz8899\">620<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6491\" page=\"584\" related-article-type=\"in-this-issue\" vol=\"368\" xlink:href=\"10.1126\/science.abb6662\">584<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aaz8899","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T23:05:38Z","timestamp":1588892738000},"page":"620-625","source":"Crossref","is-referenced-by-count":199,"title":["Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice"],"prefix":"10.1126","volume":"368","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-3885","authenticated-orcid":true,"given":"Liam M.","family":"Guthrie","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Medicine, Texas A&amp;M Health Science Center, College Station, TX 77843, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3853-7503","authenticated-orcid":true,"given":"Shivatheja","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Texas A&amp;M University, College Station, TX 77843, 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