{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:26:20Z","timestamp":1790724380316,"version":"4.1.0"},"reference-count":89,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6503","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,7,31]]},"abstract":"<jats:title>How the thymus shaped immunology<\/jats:title>\n          <jats:p>The function of the thymus was discovered by Jacques Miller in 1961 and laid a foundation for immunology and modern medicine. Until that time, researchers mistakenly believed the thymus merely represented a remnant of defunct lymph tissue, something of an immune cell graveyard. In a Review, Miller recounts the seminal experiments and conceptual thinking that led to uncovering the critical function of the thymus and provides insights that can be learned from those early days. How knowledge of thymus function subsequently spawned the field of T cell biology and the impact it has had on immune cell interactions, vaccination, cancer immunotherapy, and the microbiome are also discussed.<\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aba2429\">eaba2429<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aba2429","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T23:06:39Z","timestamp":1596150399000},"source":"Crossref","is-referenced-by-count":110,"title":["The function of the thymus and its impact on modern medicine"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-5109","authenticated-orcid":true,"given":"Jacques F. A. P.","family":"Miller","sequence":"first","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia."},{"name":"Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/196651a0"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1958.0058"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1967.47.3.437"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714478115"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091030307"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1961.38"},{"key":"e_1_3_1_8_2","unstructured":"D. Metcalf \u201cThe thymus and lymphopoiesis \u201d in The Thymus in Immunobiology R. A. Good A. E. 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