{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:25:52Z","timestamp":1790843152748,"version":"4.1.0"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6492","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,5,15]]},"abstract":"<jats:title>\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    's inner clock\n                  <\/jats:title>\n                  <jats:p>\n                    Malarial fevers are notably regular, occurring when parasitized red blood cells rupture synchronously to release replicated parasites. It has long been speculated that the\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites that cause malaria must therefore have intrinsic circadian clocks to be able to synchronize like this. Two groups have now probed gene expression in experiments and models using data obtained during the developmental cycles of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    in vitro and in the mouse model of\n                    <jats:italic>P. chabaudi<\/jats:italic>\n                    malaria. Smith\n                    <jats:italic>et al.<\/jats:italic>\n                    discovered that four strains of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    have circadian and cell cycle oscillators, each with distinctive periodicities that can be experimentally manipulated. Rijo-Ferreira\n                    <jats:italic>et al.<\/jats:italic>\n                    found that gene expression in\n                    <jats:italic>P. chabaudi<\/jats:italic>\n                    was strikingly rhythmic, persisted during constant darkness and in infections of arrhythmic mice, and synchronized by entraining to the host's periodicity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6492\" page=\"754\" related-article-type=\"in-this-issue\" vol=\"368\" xlink:href=\"10.1126\/science.aba4357\">754<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6492\" page=\"746\" related-article-type=\"in-this-issue\" vol=\"368\" xlink:href=\"10.1126\/science.aba2658\">746<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aba4357","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T19:09:47Z","timestamp":1589483387000},"page":"754-759","source":"Crossref","is-referenced-by-count":95,"title":["An intrinsic oscillator drives the blood stage cycle of the malaria parasite\n                    <i>Plasmodium falciparum<\/i>"],"prefix":"10.1126","volume":"368","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-4478","authenticated-orcid":true,"given":"Lauren M.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-5440","authenticated-orcid":true,"given":"Francis C.","family":"Motta","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1893-0567","authenticated-orcid":true,"given":"Garima","family":"Chopra","sequence":"additional","affiliation":[{"name":"Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Kathleen","family":"Moch","sequence":"additional","affiliation":[{"name":"Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9125-5855","authenticated-orcid":true,"given":"Robert R.","family":"Nerem","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Montana State University, Bozeman, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-5277","authenticated-orcid":true,"given":"Bree","family":"Cummins","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Montana State University, Bozeman, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-9393","authenticated-orcid":true,"given":"Kimberly E.","family":"Roche","sequence":"additional","affiliation":[{"name":"Program in Computational Biology and Bioinformatics, Duke University, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-1818","authenticated-orcid":true,"given":"Christina M.","family":"Kelliher","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-8224","authenticated-orcid":true,"given":"Adam R.","family":"Leman","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Harer","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Duke University, Durham, NC, 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