{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:55:36Z","timestamp":1788173736555,"version":"build-2803163510"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6499","funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1175094"],"award-info":[{"award-number":["OPP1175094"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["107652\/Z\/15\/Z"],"award-info":[{"award-number":["107652\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["757688"],"award-info":[{"award-number":["757688"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,7,3]]},"abstract":"<jats:title>Sourcing HIV-1 infection<\/jats:title>\n                  <jats:p>\n                    HIV-1 has a multitude of strain variants, but sexual transmission of HIV-1 is assumed to result from productive infection by only one virus particle. Knowing the genetics of the virus strains that are transmitted could be crucial for developing successful vaccine strategies. Using epidemiological and genetic data from 112 pairs of sexual partners, Villabona-Arenas\n                    <jats:italic>et al.<\/jats:italic>\n                    found that individuals with acute infections are more likely to transmit multiple founder virus strains. In a phylodynamic approach that integrated phylogenetic analysis of sequence data with simulation of a transmission chain, the authors showed that multiple variant transmission is doubled during the first 3 months of infection irrespective of whether transmission was heterosexual or by men who have sex with men.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6499\" page=\"103\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.aba5443\">103<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aba5443","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T19:05:53Z","timestamp":1593716753000},"page":"103-108","source":"Crossref","is-referenced-by-count":15,"title":["Number of HIV-1 founder variants is determined by the recency of the source partner infection"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-3968","authenticated-orcid":true,"given":"Ch. Juli\u00e1n","family":"Villabona-Arenas","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK."},{"name":"Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-3864","authenticated-orcid":true,"given":"Matthew","family":"Hall","sequence":"additional","affiliation":[{"name":"Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina A.","family":"Lythgoe","sequence":"additional","affiliation":[{"name":"Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-2945","authenticated-orcid":true,"given":"Stephen G.","family":"Gaffney","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8319-5293","authenticated-orcid":true,"given":"Roland R.","family":"Regoes","sequence":"additional","affiliation":[{"name":"Institute of Integrative Biology, Department of Environmental Systems Science, ETH Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-6905","authenticated-orcid":true,"given":"St\u00e9phane","family":"Hu\u00e9","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK."},{"name":"Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5250-0558","authenticated-orcid":true,"given":"Katherine E.","family":"Atkins","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK."},{"name":"Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK."},{"name":"Centre for Global Health, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2016.0727"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-017-0343-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004092"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802203105"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02660-07"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02132-08"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000890"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002209"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005619"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2012.0595"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-325860"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e3283504941"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu369"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vey038"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522930113"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09139-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx304"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0204-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy734"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001728"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00811-18"},{"key":"e_1_3_2_23_2","first-page":"67","article-title":"HIV-1 drug resistance mutations: An updated framework for the second decade of HAART","volume":"10","author":"Shafer R. 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