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Lawson\n            <jats:italic>et al.<\/jats:italic>\n            and Li\n            <jats:italic>et al.<\/jats:italic>\n            examined the genetic composition of laser-dissected microbiopsies from normal and cancer cells collected from the urothelium, a specialized epithelium lining the lower urinary tract (see the Perspective by Rozen). These complementary studies identified the mutational landscape of bladder urothelium through various sequencing strategies and identified high mutational heterogeneity within and between individuals and tumors. Both studies identified mutational profiles related to specific carcinogens such as aristolochic acid and the molecules found in tobacco. These studies present a comprehensive description of the diverse mutational landscape of the human bladder in health and disease, unraveling positive selection for cancer-causing mutations, a diversity of mutational processes, and large differences across individuals.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6512\" page=\"75\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.aba8347\">75<\/jats:related-article>\n            , p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6512\" page=\"82\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.aba7300\">82<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6512\" page=\"34\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abe0955\">34<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aba7300","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T23:20:23Z","timestamp":1602804023000},"page":"82-89","source":"Crossref","is-referenced-by-count":195,"title":["Macroscopic somatic clonal expansion in morphologically normal human urothelium"],"prefix":"10.1126","volume":"370","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-9729","authenticated-orcid":true,"given":"Ruoyan","family":"Li","sequence":"first","affiliation":[{"name":"Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, 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