{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:45:54Z","timestamp":1792759554388,"version":"4.5.0"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6527","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI 102888"],"award-info":[{"award-number":["R01 AI 102888"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA08748"],"award-info":[{"award-number":["P30 CA08748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["Faculty Scholar Award"],"award-info":[{"award-number":["Faculty Scholar Award"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,1,22]]},"abstract":"<jats:title>A metabolic circuit in T cell immunity<\/jats:title>\n                  <jats:p>\n                    Na\u00efve T cells are metabolically reprogrammed when they differentiate into T effector (T\n                    <jats:sub>eff<\/jats:sub>\n                    ) cells, transitioning from a reliance on mitochondrial oxidative phosphorylation to aerobic glycolysis. Xu\n                    <jats:italic>et al.<\/jats:italic>\n                    found that lactate dehydrogenase A (LDHA), a glycolytic enzyme that converts pyruvate to lactate, is a key player in this process. T\n                    <jats:sub>eff<\/jats:sub>\n                    cells that differentiate in mice infected with the bacterium\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    turned on LDHA through phosphoinositide 3-kinase (PI3K) signaling. By promoting adenosine triphosphate (ATP) production, LDHA in turn facilitated PI3K-dependent inactivation of the transcription factor Foxo1 needed for effective T\n                    <jats:sub>eff<\/jats:sub>\n                    cell responses. Thus, glycolytic ATP acts like a rheostat that both gauges and regulates PI3K-dependent signaling. This type of positive feedback circuit may also provide a mechanistic explanation for the Warburg effect observed in cancer cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6527\" page=\"405\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.abb2683\">405<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abb2683","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T15:20:47Z","timestamp":1611242447000},"page":"405-410","source":"Crossref","is-referenced-by-count":345,"title":["Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity"],"prefix":"10.1126","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-1052","authenticated-orcid":true,"given":"Ke","family":"Xu","sequence":"first","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"name":"Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8280-6512","authenticated-orcid":true,"given":"Na","family":"Yin","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5885-0660","authenticated-orcid":true,"given":"Min","family":"Peng","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-9005","authenticated-orcid":true,"given":"Efstathios G.","family":"Stamatiades","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9 University Medical Centre, 12203 Berlin, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Shyu","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"name":"Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3893-076X","authenticated-orcid":true,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9674-7886","authenticated-orcid":true,"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mytrang H.","family":"Do","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"name":"Immunology and Microbial Pathogenesis Graduate 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USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Chou","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Levine","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"name":"Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Y.","family":"Rudensky","sequence":"additional","affiliation":[{"name":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."},{"name":"Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 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