{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:19:15Z","timestamp":1790666355081,"version":"4.1.0"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6510","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA202704"],"award-info":[{"award-number":["R01 CA202704"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,9,18]]},"abstract":"<jats:title>Microbiota protect the kidneys<\/jats:title>\n                  <jats:p>\n                    Chronic kidney disease (CKD) afflicts millions of people globally. The first-line treatment for CKD is dietary intervention, so there may be a gut microbiota\u2013associated component. Lobel\n                    <jats:italic>et al.<\/jats:italic>\n                    investigated the mechanistic links between the microbiota and protein intake, because the protein metabolites indole and indoxyl sulfate are known uremic toxins (see the Perspective by Pluznick). The authors used a mouse model of CKD precipitated by a paucity of the dietary sulfur\u2013containing amino acids methionine and cysteine. Bacterial metabolism of sulfur-containing amino acids modulated indole production by sulfide inhibition of the enzyme tryptophanase, thus abrogating uremic toxicity by this metabolite in this model system.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6510\" page=\"1518\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.abb3763\">1518<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6510\" page=\"1426\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.abd8344\">1426<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abb3763","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T19:10:20Z","timestamp":1600369820000},"page":"1518-1524","source":"Crossref","is-referenced-by-count":199,"title":["Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-5839","authenticated-orcid":true,"given":"Lior","family":"Lobel","sequence":"first","affiliation":[{"name":"Departments of Immunology and Infectious Diseases and Molecular Metabolism, Harvard T.H. 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