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The envelope protein (E) on the virus surface has been the target of vaccine development, but problems have arisen with antibodies against E, leading to enhanced infection. Now, Modhiran\n            <jats:italic>et al.<\/jats:italic>\n            and Biering\n            <jats:italic>et al.<\/jats:italic>\n            describe two different antibodies that bind to the flavivirus NS1 protein and prevent it from disrupting epithelial cells, which is associated with severe disease. Both antibodies cross-react with multiple flavivirus NS1 proteins. The antibodies reduce viremia and increase survival in mouse models of flavivirus disease. Both papers include structures of NS1 bound to an antibody, which give insight into the protective mechanism.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6525\" page=\"190\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.abb9425\">190<\/jats:related-article>\n            , p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6525\" page=\"194\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.abc0476\">194<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.abb9425","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T20:31:44Z","timestamp":1610051504000},"page":"190-194","source":"Crossref","is-referenced-by-count":126,"title":["A broadly protective antibody that targets the flavivirus NS1 protein"],"prefix":"10.1126","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-4970","authenticated-orcid":true,"given":"Naphak","family":"Modhiran","sequence":"first","affiliation":[{"name":"Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-0370","authenticated-orcid":true,"given":"Hao","family":"Song","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China."},{"name":"Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidong","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Bletchly","sequence":"additional","affiliation":[{"name":"Microbiology, Pathology Queensland, Queensland Health, Herston, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lou","family":"Brillault","sequence":"additional","affiliation":[{"name":"Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia."},{"name":"Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6640-3377","authenticated-orcid":true,"given":"Alberto A.","family":"Amarilla","sequence":"additional","affiliation":[{"name":"Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Xu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-4732","authenticated-orcid":true,"given":"Jianxun","family":"Qi","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1912-3620","authenticated-orcid":true,"given":"Yan","family":"Chai","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T. 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