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A leading theory is that virus-infected cells secrete paracrine signaling molecules that dysregulate epithelial cells. Chang-Graham\n                    <jats:italic>et al.<\/jats:italic>\n                    found that rotavirus-infected cells trigger cell-to-cell signaling that manifests as intercellular calcium waves (see the Perspective by Stanifer and Boulant). This signal results from the repeated release of adenosine 5\u2032-diphosphate by rotavirus-infected cells. This release activates receptors on nearby uninfected cells, resulting in a calcium signal. The intercellular calcium waves activate chloride and serotonin secretion, which contributes to diarrhea and vomiting. Blocking this paracrine signal could represent a target for antidiarrheal pharmacotherapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abc3621\">eabc3621<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6519\" page=\"909\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abf1914\">909<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abc3621","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T20:37:49Z","timestamp":1605818269000},"source":"Crossref","is-referenced-by-count":81,"title":["Rotavirus induces intercellular calcium waves through ADP signaling"],"prefix":"10.1126","volume":"370","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-6787","authenticated-orcid":true,"given":"Alexandra L.","family":"Chang-Graham","sequence":"first","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA."},{"name":"Alkek Center for Metagenomic and Microbiome Research, Baylor College of Medicine, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-9266","authenticated-orcid":true,"given":"Jacob L.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA."},{"name":"Alkek Center for Metagenomic and Microbiome Research, Baylor College of Medicine, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-9932","authenticated-orcid":true,"given":"Melinda A.","family":"Engevik","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA."},{"name":"Department of Pathology, Texas Children\u2019s Hospital, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-1875","authenticated-orcid":true,"given":"Kristen A.","family":"Engevik","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA."},{"name":"Alkek Center for Metagenomic and Microbiome Research, Baylor College of Medicine, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6324","authenticated-orcid":true,"given":"Francesca J.","family":"Scribano","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA."},{"name":"Alkek Center for Metagenomic and Microbiome Research, Baylor College of Medicine, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-8972","authenticated-orcid":true,"given":"J. 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