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Gu\n            <jats:italic>et al.<\/jats:italic>\n            developed a mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia. Adaptation of this viral strain in the mouse appeared to be dependent on a critical amino acid change, Asn\n            <jats:sup>501<\/jats:sup>\n            to Tyr (N501Y), within the receptor-binding domain of the viral spike protein. The new mouse model was used to study neutralizing antibodies and a vaccine candidate against the virus.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6511\" page=\"1603\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.abc4730\">1603<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.abc4730","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T23:16:08Z","timestamp":1596150968000},"page":"1603-1607","source":"Crossref","is-referenced-by-count":753,"title":["Adaptation of SARS-CoV-2 in BALB\/c mice for testing vaccine efficacy"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-5798","authenticated-orcid":true,"given":"Hongjing","family":"Gu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-7267","authenticated-orcid":true,"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-6976","authenticated-orcid":true,"given":"Guan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Proteomics, 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