{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:08:58Z","timestamp":1792447738355,"version":"4.5.0"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6508","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI090023"],"award-info":[{"award-number":["U19AI090023"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,9,4]]},"abstract":"<jats:title>Immune profiling of COVID-19 patients<\/jats:title>\n                  <jats:p>\n                    Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew\n                    <jats:italic>et al.<\/jats:italic>\n                    present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam\n                    <jats:italic>et al.<\/jats:italic>\n                    report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abc8511\">eabc8511<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6508\" page=\"1210\" related-article-type=\"in-this-issue\" vol=\"369\" xlink:href=\"10.1126\/science.abc6261\">1210<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abc6261","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T15:17:22Z","timestamp":1597159042000},"page":"1210-1220","source":"Crossref","is-referenced-by-count":1163,"title":["Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans"],"prefix":"10.1126","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0090-5689","authenticated-orcid":true,"given":"Prabhu S.","family":"Arunachalam","sequence":"first","affiliation":[{"name":"Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-2228","authenticated-orcid":true,"given":"Florian","family":"Wimmers","sequence":"additional","affiliation":[{"name":"Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-6772","authenticated-orcid":true,"given":"Chris Ka Pun","family":"Mok","sequence":"additional","affiliation":[{"name":"HKU-Pasteur Research Pole, School of Public Health, HKU Li Ka Shing Faculty of Medicine, The University of Hong Kong (HKU), Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-1535","authenticated-orcid":true,"given":"Ranawaka A. 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