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Although severe dengue symptoms are associated with increased levels of afucosylated IgG1 glycoforms, it is unclear whether this is simply a result of the infection or if it is a preexisting phenomenon that can dictate susceptibility to this disease. Bournazos\n                    <jats:italic>et al.<\/jats:italic>\n                    studied the Fab and Fc structures of anti-DENV antibodies from patients before and after infection and with variable disease outcomes (see the Perspective by de Alwis and Ooi). They found that DENV infection induced specific increases in IgG1 afucosylation, and levels of afucosylated IgG1 could indeed predict dengue disease severity, making IgG1 fucosylation status a potentially useful prognostic tool for the treatment of dengue patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , abc7303, this issue p.\n                    <jats:related-article issue=\"6546\" page=\"1102\" related-article-type=\"in-this-issue\" vol=\"372\">1102<\/jats:related-article>\n                    ; see also abj0435, p.\n                    <jats:related-article issue=\"6546\" page=\"1041\" related-article-type=\"in-this-issue\" vol=\"372\">1041<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abc7303","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T15:24:54Z","timestamp":1622733894000},"page":"1102-1105","source":"Crossref","is-referenced-by-count":135,"title":["Antibody fucosylation predicts disease severity in secondary dengue infection"],"prefix":"10.1126","volume":"372","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-5620","authenticated-orcid":true,"given":"Stylianos","family":"Bournazos","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8694-5272","authenticated-orcid":true,"given":"Hoa Thi My","family":"Vo","sequence":"additional","affiliation":[{"name":"Immunology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-1678","authenticated-orcid":true,"given":"Veasna","family":"Duong","sequence":"additional","affiliation":[{"name":"Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-7618","authenticated-orcid":true,"given":"Heidi","family":"Auerswald","sequence":"additional","affiliation":[{"name":"Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-5445","authenticated-orcid":true,"given":"Sowath","family":"Ly","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-6937","authenticated-orcid":true,"given":"Anavaj","family":"Sakuntabhai","sequence":"additional","affiliation":[{"name":"Functional Genetics of Infectious Diseases Unit, Department of Global Health, Institut Pasteur, Paris Cedex 15, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR2000, Paris Cedex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-3037","authenticated-orcid":true,"given":"Philippe","family":"Dussart","sequence":"additional","affiliation":[{"name":"Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-1502","authenticated-orcid":true,"given":"Tineke","family":"Cantaert","sequence":"additional","affiliation":[{"name":"Immunology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-9041","authenticated-orcid":true,"given":"Jeffrey V.","family":"Ravetch","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/315215"},{"key":"e_1_3_2_4_2","first-page":"311","article-title":"Observations related to pathogenesis of dengue hemorrhagic fever. 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