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These regions interact with disparate immune cell receptors and complement proteins to help instruct distinct immune responses. The Fc domain of immunoglobulin G (IgG) antibodies contains a conserved N-linked glycan at position 297. However, the particular glycan used at this position is highly variable. IgG lacking core fucosylation at this position initiates enhanced antibody-dependent cellular cytotoxicity by increased affinity to the Fc receptor FcRIIIa. Larsen\n                    <jats:italic>et al.<\/jats:italic>\n                    report that COVID-19 patients with severe symptoms have increased levels of anti\u2013severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG afucosylation compared with patients with mild disease. These findings suggest that treatment of COVID-19 patients with fucosylated anti\u2013SARS-CoV-2 antibodies may circumvent pathologies associated with severe COVID-19.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abc8378\">eabc8378<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abc8378","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T16:31:34Z","timestamp":1608741094000},"source":"Crossref","is-referenced-by-count":366,"title":["Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity"],"prefix":"10.1126","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-5901","authenticated-orcid":true,"given":"Mads Delbo","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands."},{"name":"Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-831X","authenticated-orcid":true,"given":"Erik L.","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands."},{"name":"Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrthe E.","family":"Sonneveld","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands."},{"name":"Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4520-3103","authenticated-orcid":true,"given":"H. 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