{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:31:27Z","timestamp":1791873087895,"version":"4.3.4"},"reference-count":37,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6518","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ERC CoV"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,11,13]]},"abstract":"<jats:title>Another host factor for SARS-CoV-2<\/jats:title>\n                  <jats:p>\n                    Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a receptor; however, their tissue tropism differs, raising the possibility that additional host factors are involved. The spike protein of SARS-CoV-2 contains a cleavage site for the protease furin that is absent from SARS-CoV (see the Perspective by Kielian). Cantuti-Castelvetri\n                    <jats:italic>et al.<\/jats:italic>\n                    now show that neuropilin-1 (NRP1), which is known to bind furin-cleaved substrates, potentiates SARS-CoV-2 infectivity. NRP1 is abundantly expressed in the respiratory and olfactory epithelium, with highest expression in endothelial and epithelial cells. Daly\n                    <jats:italic>et al.<\/jats:italic>\n                    found that the furin-cleaved S1 fragment of the spike protein binds directly to cell surface NRP1 and blocking this interaction with a small-molecule inhibitor or monoclonal antibodies reduced viral infection in cell culture. Understanding the role of NRP1 in SARS-CoV-2 infection may suggest potential targets for future antiviral therapeutics.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6518\" page=\"856\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abd2985\">856<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6518\" page=\"861\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abd3072\">861<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6518\" page=\"765\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abf0732\">765<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abd2985","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T15:10:15Z","timestamp":1603206615000},"page":"856-860","source":"Crossref","is-referenced-by-count":1745,"title":["Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity"],"prefix":"10.1126","volume":"370","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-1610","authenticated-orcid":true,"given":"Ludovico","family":"Cantuti-Castelvetri","sequence":"first","affiliation":[{"name":"Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany."},{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7876-4607","authenticated-orcid":true,"given":"Ravi","family":"Ojha","sequence":"additional","affiliation":[{"name":"Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-647X","authenticated-orcid":true,"given":"Liliana D.","family":"Pedro","sequence":"additional","affiliation":[{"name":"Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany."},{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7759-6557","authenticated-orcid":true,"given":"Minou","family":"Djannatian","sequence":"additional","affiliation":[{"name":"Institute of Neuronal Cell 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