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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a receptor; however, their tissue tropism differs, raising the possibility that additional host factors are involved. The spike protein of SARS-CoV-2 contains a cleavage site for the protease furin that is absent from SARS-CoV (see the Perspective by Kielian). Cantuti-Castelvetri\n                    <jats:italic>et al.<\/jats:italic>\n                    now show that neuropilin-1 (NRP1), which is known to bind furin-cleaved substrates, potentiates SARS-CoV-2 infectivity. NRP1 is abundantly expressed in the respiratory and olfactory epithelium, with highest expression in endothelial and epithelial cells. Daly\n                    <jats:italic>et al.<\/jats:italic>\n                    found that the furin-cleaved S1 fragment of the spike protein binds directly to cell surface NRP1 and blocking this interaction with a small-molecule inhibitor or monoclonal antibodies reduced viral infection in cell culture. Understanding the role of NRP1 in SARS-CoV-2 infection may suggest potential targets for future antiviral therapeutics.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6518\" page=\"856\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abd2985\">856<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6518\" page=\"861\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abd3072\">861<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6518\" page=\"765\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abf0732\">765<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abd3072","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T15:10:12Z","timestamp":1603206612000},"page":"861-865","source":"Crossref","is-referenced-by-count":1171,"title":["Neuropilin-1 is a host factor for SARS-CoV-2 infection"],"prefix":"10.1126","volume":"370","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4551-1256","authenticated-orcid":true,"given":"James L.","family":"Daly","sequence":"first","affiliation":[{"name":"School of Biochemistry, Faculty of Life Sciences, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-6640","authenticated-orcid":true,"given":"Boris","family":"Simonetti","sequence":"additional","affiliation":[{"name":"School of Biochemistry, Faculty of Life Sciences, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-4597","authenticated-orcid":true,"given":"Katja","family":"Klein","sequence":"additional","affiliation":[{"name":"School of Cellular and Molecular Medicine, Faculty of Life Sciences, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-1629","authenticated-orcid":true,"given":"Kai-En","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, the University of Queensland, St. Lucia, QLD 4072, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4659-8613","authenticated-orcid":true,"given":"Maia 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