{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:37:26Z","timestamp":1790775446506,"version":"4.1.0"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6519","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,11,20]]},"abstract":"<jats:title>Domesticating Zika virus<\/jats:title>\n                  <jats:p>\n                    Why hasn't Zika virus (ZIKV) disease caused as much devastation in Africa, its continent of origin, as it has in the Americas? Outside of Africa, this flavivirus is transmitted by a ubiquitous mosquito subspecies,\n                    <jats:italic>Aedes aegypti aegypti<\/jats:italic>\n                    , which emerged from the African forerunner subspecies\n                    <jats:italic>A. aegypti formosus<\/jats:italic>\n                    and acquired a preference for human blood and a peridomestic lifestyle. Now, this subspecies colonizes many intertropical cities, aided by climate change and human trash. Aubry\n                    <jats:italic>et al.<\/jats:italic>\n                    tested 14 laboratory mosquito colonies for their relative susceptibility to ZIKV. Quantitative trait locus mapping showed differences on chromosome 2 between mosquitoes from Gabon and Guadeloupe. Mouse infection experiments revealed that African mosquitoes transmitted a smaller virus inoculum than the South American insects. Increased susceptibility coupled with the ability of\n                    <jats:italic>A. aegypti aegypti<\/jats:italic>\n                    to breed in any discarded object containing water has amplified the problematic nature of this virus as it has circumnavigated the world.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article issue=\"6519\" page=\"991\" related-article-type=\"in-this-issue\" vol=\"370\">991<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abd3663","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T20:37:49Z","timestamp":1605818269000},"page":"991-996","source":"Crossref","is-referenced-by-count":117,"title":["Enhanced Zika virus susceptibility of globally invasive\n                    <i>Aedes aegypti<\/i>\n                    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