{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:44:30Z","timestamp":1790775870941,"version":"4.1.0"},"reference-count":79,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6549","funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-20-CE17-0008_CA-Ts, ANR-18-CE12-0010_ZFun"],"award-info":[{"award-number":["ANR-20-CE17-0008_CA-Ts, ANR-18-CE12-0010_ZFun"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003768","name":"Universit\u00e9 de Strasbourg","doi-asserted-by":"publisher","award":["USIAS-2015-42"],"award-info":[{"award-number":["USIAS-2015-42"]}],"id":[{"id":"10.13039\/501100003768","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007175","name":"Conseil National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["ANR-20-CE17-0008"],"award-info":[{"award-number":["ANR-20-CE17-0008"]}],"id":[{"id":"10.13039\/501100007175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007175","name":"Conseil National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["ANR-18-CE12-0010"],"award-info":[{"award-number":["ANR-18-CE12-0010"]}],"id":[{"id":"10.13039\/501100007175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007175","name":"Conseil National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["ANR-16-BSV8-0013"],"award-info":[{"award-number":["ANR-16-BSV8-0013"]}],"id":[{"id":"10.13039\/501100007175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011658","name":"French Infrastructure for Integrated Structural Biology","doi-asserted-by":"publisher","award":["ANR-10-INSB-05-01"],"award-info":[{"award-number":["ANR-10-INSB-05-01"]}],"id":[{"id":"10.13039\/501100011658","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IGBMC Microarray and Sequencing","award":["ANR-10-INBS-0009"],"award-info":[{"award-number":["ANR-10-INBS-0009"]}]},{"DOI":"10.13039\/501100004099","name":"La Ligue Nationale Contre le Cancer","doi-asserted-by":"crossref","award":["Equipe Labellisee AH_2019"],"award-info":[{"award-number":["Equipe Labellisee AH_2019"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:title>MeCP2 binds hydroxymethylated CA repeats<\/jats:title>\n                  <jats:p>\n                    Despites of decades of research on the Rett syndrome protein MeCP2, its function remains unclear. Ibrahim\n                    <jats:italic>et al.<\/jats:italic>\n                    show that MeCP2 is a hydroxymethylated cytosine-adenosine (CA) repeat-binding protein that modulates chromatin architecture at a distance from the transcription start site (see the Perspective by Zhou and Zoghbi). MeCP2 accumulates and spreads around modified CA repeats and competes for nucleosome occupancy. Loss of MeCP2 results in a widespread increase in nucleosome density inside lamina-associated domains and transcriptional dysregulation of genes enriched in CA repeats. These results shed light on the underlying molecular mechanism of Rett syndrome, a severe disease associated with mutations in MeCP2.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , abd5581, this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abd5581\">eabd5581<\/jats:related-article>\n                    ; see also abj5027, p.\n                    <jats:related-article issue=\"6549\" page=\"1390\" related-article-type=\"in-this-issue\" vol=\"372\">1390<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abd5581","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T20:45:22Z","timestamp":1624567522000},"source":"Crossref","is-referenced-by-count":60,"title":["MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion"],"prefix":"10.1126","volume":"372","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1035-8044","authenticated-orcid":true,"given":"Abdulkhaleg","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France."},{"name":"Department of Functional Genomics and Cancer, IGBMC, CNRS, INSERM, Universit\u00e9 de Strasbourg, 67404 Illkirch, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U964, 67404 Illkirch, France."},{"name":"Universit\u00e9 de Strasbourg, 67404 Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8124-5883","authenticated-orcid":true,"given":"Christophe","family":"Papin","sequence":"additional","affiliation":[{"name":"Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France."},{"name":"Department of Functional Genomics and Cancer, IGBMC, CNRS, INSERM, Universit\u00e9 de Strasbourg, 67404 Illkirch, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U964, 67404 Illkirch, France."},{"name":"Universit\u00e9 de Strasbourg, 67404 Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7426-5093","authenticated-orcid":true,"given":"Kareem","family":"Mohideen-Abdul","sequence":"additional","affiliation":[{"name":"Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U964, 67404 Illkirch, France."},{"name":"Universit\u00e9 de Strasbourg, 67404 Illkirch, France."},{"name":"Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, INSERM, Universit\u00e9 de Strasbourg, 67404 Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Le Gras","sequence":"additional","affiliation":[{"name":"Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U964, 67404 Illkirch, France."},{"name":"Universit\u00e9 de Strasbourg, 67404 Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Stoll","sequence":"additional","affiliation":[{"name":"Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France."},{"name":"Department of Functional Genomics and Cancer, IGBMC, CNRS, INSERM, Universit\u00e9 de Strasbourg, 67404 Illkirch, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U964, 67404 Illkirch, France."},{"name":"Universit\u00e9 de Strasbourg, 67404 Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bronner","sequence":"additional","affiliation":[{"name":"Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France."},{"name":"Department of Functional Genomics and Cancer, IGBMC, CNRS, INSERM, Universit\u00e9 de Strasbourg, 67404 Illkirch, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U964, 67404 Illkirch, France."},{"name":"Universit\u00e9 de Strasbourg, 67404 Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1326-3630","authenticated-orcid":true,"given":"Stefan","family":"Dimitrov","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, CNRS UMR 5309, INSERM U1209, Institute for Advanced Biosciences (IAB), Site Sant\u00e9 - All\u00e9e des Alpes, 38700 La Tronche, France."},{"name":"Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8674-8674","authenticated-orcid":true,"given":"Bruno P.","family":"Klaholz","sequence":"additional","affiliation":[{"name":"Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U964, 67404 Illkirch, France."},{"name":"Universit\u00e9 de Strasbourg, 67404 Illkirch, France."},{"name":"Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, INSERM, Universit\u00e9 de Strasbourg, 67404 Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7859-6372","authenticated-orcid":true,"given":"Ali","family":"Hamiche","sequence":"additional","affiliation":[{"name":"Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 67400 Illkirch, France."},{"name":"Department of Functional Genomics and Cancer, IGBMC, CNRS, INSERM, Universit\u00e9 de Strasbourg, 67404 Illkirch, France."},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France."},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U964, 67404 Illkirch, France."},{"name":"Universit\u00e9 de Strasbourg, 67404 Illkirch, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"723","article-title":"[On a unusual brain atrophy syndrome in hyperammonemia in childhood]","volume":"116","author":"Rett A.","year":"1966","unstructured":"A. Rett, [On a unusual brain atrophy syndrome in hyperammonemia in childhood]. Wien. Med. Wochenschr. 116, 723\u2013726 (1966). 5300597","journal-title":"Wien. Med. Wochenschr."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140412"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200005)47:5<670::AID-ANA20>3.0.CO;2-F"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2005.04.003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/85899"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/85906"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3897"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3434"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90610-O"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.19.5085"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0001271"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.21.4172"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14319"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708044114"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006793"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.022"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.004"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi500424z"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411269112"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618737114"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.047"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.213983.116"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.011"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.002"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700855200"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0521-9"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3461"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.08.022"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.26921"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237905"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108416"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184577"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.07.002"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.12.028"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3023"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.01.011"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08514"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.022"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.03.016"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.009"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.6.1595"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.19.13176"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.01974.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5660803"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2016-0190"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12922"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090710"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr167"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw257"},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","unstructured":"H. Wickham ggplot2: Elegant Graphics for Data Analysis (Springer-Verlag 2016).","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153252"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp181"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1066"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.038"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.08.001"},{"key":"e_1_3_2_63_2","doi-asserted-by":"crossref","unstructured":"A. Sanfeliu W. E. Kaufmann M. Gill P. Guasoni D. Tropea Transcriptomic studies in mouse models of Rett syndrome: A review. Neuroscience 413 183\u2013205 (2019). 10.1016\/j.neuroscience.2019.06.01331229631","DOI":"10.1016\/j.neuroscience.2019.06.013"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1287"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.004"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1159\/000084979"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth349"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1093"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1177\/1087057115618347"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444911007773"},{"key":"e_1_3_2_73_2","unstructured":"I. J. Tickle C. Flensburg P. Keller W. Paciorek A. Sharff C. Vonrhein G. Bricogne STARANISO (Global Phasing Ltd. 2017); http:\/\/staraniso.globalphasing.org\/cgi-bin\/staraniso.cgi."},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902016657"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"e_1_3_2_77_2","unstructured":"G. Bricogne E. Blanc M. Brandl C. Flensburg P. Keller W. Paciorek P. Roversi A. Sharff O. S. Smart C. Vonrhein T. O. Womack BUSTER version 2.10.3 (Global Phasing Ltd. 2017)."},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg680"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr316"},{"key":"e_1_3_2_80_2","unstructured":"W. L. DeLano The PyMOL Molecular Graphics System Version 1.7.0.1 (Schr\u00f6dinger LLC 2002) ."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/science.abd5581","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.abd5581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T17:30:15Z","timestamp":1705339815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.abd5581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":79,"journal-issue":{"issue":"6549","published-print":{"date-parts":[[2021,6,25]]}},"alternative-id":["10.1126\/science.abd5581"],"URL":"https:\/\/doi.org\/10.1126\/science.abd5581","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740356486.793587505","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]},"article-number":"eabd5581"}}