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None provokes fully protective immunity, and repeat infections are the norm. Vaccines tend to be less efficient than natural infections at provoking immunity, and there are risks of adverse cross-reactions. Saad-Roy<jats:italic>et al.<\/jats:italic>used a series of simple models for a variety of immune scenarios to envisage immunological futures for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without vaccines. The model outcomes show that our imperfect knowledge about the imperfect coronavirus immune landscape can give rise to diverging scenarios ranging from recurring severe epidemics to elimination. 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