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Building on work implicating the reactive small-molecule hydrogen sulfide in bacterial defense against antibiotics, Shatalin\n                    <jats:italic>et al.<\/jats:italic>\n                    conducted a structure-based screen for inhibitors of a bacterial hydrogen sulfide\u2013producing enzyme and found a group of inhibitors that act through an allosteric mechanism (see the Perspective by Mah). These inhibitors potentiated bactericidal antibiotics in vitro and in mouse infection models. They also suppressed persister bacteria and disrupted biofilm formation. This strategy of taking out persister cells may be promising for treating recalcitrant infections and holding the line against drug-resistant bacteria.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , abd8377, this issue p.\n                    <jats:related-article issue=\"6547\" page=\"1169\" related-article-type=\"in-this-issue\" vol=\"372\">1169<\/jats:related-article>\n                    ; see also abj3062, p.\n                    <jats:related-article issue=\"6547\" page=\"1153\" related-article-type=\"in-this-issue\" vol=\"372\">1153<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abd8377","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T15:15:57Z","timestamp":1623338157000},"page":"1169-1175","source":"Crossref","is-referenced-by-count":273,"title":["Inhibitors of bacterial H\n                    <sub>2<\/sub>\n           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