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Kirschstein Postdoctoral Individual National Research Service Award","award":["F32GM125217"],"award-info":[{"award-number":["F32GM125217"]}]},{"name":"Esther and A. & Joseph Klingenstein Fund"},{"DOI":"10.13039\/501100007469","name":"Alfred Benzon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,12,18]]},"abstract":"<jats:title>Nanobodies that neutralize<\/jats:title>\n                  <jats:p>\n                    Monoclonal antibodies that bind to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show therapeutic promise but must be produced in mammalian cells and need to be delivered intravenously. By contrast, single-domain antibodies called nanobodies can be produced in bacteria or yeast, and their stability may enable aerosol delivery. Two papers now report nanobodies that bind tightly to spike and efficiently neutralize SARS-CoV-2 in cells. Schoof\n                    <jats:italic>et al.<\/jats:italic>\n                    screened a yeast surface display of synthetic nanobodies and Xiang\n                    <jats:italic>et al.<\/jats:italic>\n                    screened anti-spike nanobodies produced by a llama. Both groups identified highly potent nanobodies that lock the spike protein in an inactive conformation. Multivalent constructs of selected nanobodies achieved even more potent neutralization.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6523\" page=\"1473\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abe3255\">1473<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6523\" page=\"1479\" related-article-type=\"in-this-issue\" vol=\"370\" xlink:href=\"10.1126\/science.abe4747\">1479<\/jats:related-article>\n                  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