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The number of senescent cells increases with advanced age and this in turn drives age-related diseases. Camell\n                    <jats:italic>et al.<\/jats:italic>\n                    show that senescent cells have an amplified inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (see the Perspective by Cox and Lord). This response is communicated to nonsenescent cells, suppressing viral defense mechanisms and increasing the expression of viral entry proteins. In old mice infected with a SARS-CoV-2\u2013related virus, treatment with senolytics to reduce the senolytic cell burden reduced mortality and increased antiviral antibodies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , abe4832, this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abe4832\">eabe4832<\/jats:related-article>\n                    ; see also abi4474, p.\n                    <jats:related-article issue=\"6552\" page=\"281\" related-article-type=\"in-this-issue\" vol=\"373\">281<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abe4832","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T11:30:53Z","timestamp":1623151853000},"source":"Crossref","is-referenced-by-count":314,"title":["Senolytics reduce coronavirus-related mortality in old mice"],"prefix":"10.1126","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7847-3543","authenticated-orcid":true,"given":"Christina D.","family":"Camell","sequence":"first","affiliation":[{"name":"Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-1029","authenticated-orcid":true,"given":"Matthew J.","family":"Yousefzadeh","sequence":"additional","affiliation":[{"name":"Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-3156","authenticated-orcid":true,"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA."},{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9617-8089","authenticated-orcid":true,"given":"Larissa G. 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