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Monoclonal antibodies are an important weapon in the battle against COVID-19. However, these large proteins are difficult to produce in the needed quantities and at low cost. Attention has turned to nanobodies, which are aptly named, single-domain antibodies that are easier to produce and have the potential to be administered by inhalation. Koenig\n                    <jats:italic>et al.<\/jats:italic>\n                    describe four nanobodies that bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prevent infection of cells (see the Perspective by Saelens and Schepens). Structures show that the nanobodies target two distinct epitopes on the SARS-CoV-2 spike protein. Multivalent nanobodies neutralize virus much more potently than single nanobodies, and multivalent nanobodies that bind two epitopes prevent the emergence of viral escape mutants.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abe6230\">eabe6230<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6530\" page=\"681\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.abg2294\">681<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abe6230","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T13:53:37Z","timestamp":1610459617000},"source":"Crossref","is-referenced-by-count":393,"title":["Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape"],"prefix":"10.1126","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-2557","authenticated-orcid":true,"given":"Paul-Albert","family":"Koenig","sequence":"first","affiliation":[{"name":"Core Facility Nanobodies, Medical Faculty, University of Bonn, 53127 Bonn, Germany."},{"name":"Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-7065","authenticated-orcid":true,"given":"Hrishikesh","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-7853","authenticated-orcid":true,"given":"Hejun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate M.","family":"K\u00fcmmerer","sequence":"additional","affiliation":[{"name":"Institute of Virology, Medical Faculty, University of Bonn, 53127 Bonn, Germany."},{"name":"German Centre for Infection Research (DZIF), partner site Bonn-Cologne, 53127 Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-8431","authenticated-orcid":true,"given":"Florian N.","family":"Gohr","sequence":"additional","affiliation":[{"name":"Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-4590","authenticated-orcid":true,"given":"Lea-Marie","family":"Jenster","sequence":"additional","affiliation":[{"name":"Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2301-1610","authenticated-orcid":true,"given":"Lisa D. 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