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Although HDL is mainly produced by the liver, the intestine is also a source. Han\n                    <jats:italic>et al.<\/jats:italic>\n                    show in mice that intestinal HDL is not routed to the systemic circulation. Rather, in the form of HDL3, it is directly transported to the liver through the hepatic portal vein. There, it sequesters bacterial lipopolysaccharide from the gut that can trigger inflammation and liver damage. In various models of liver injury, loss of enteric HDL exacerbated pathology. By contrast, drugs elevating intestinal HDL improved disease outcomes. HDL3 is enriched in human portal venous blood, suggesting that enteric HDL may be targetable for the treatment of liver disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , abe6729, this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abe6729\">eabe6729<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abe6729","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T15:10:19Z","timestamp":1626966619000},"source":"Crossref","is-referenced-by-count":210,"title":["Enterically derived high-density lipoprotein restrains liver injury through the portal vein"],"prefix":"10.1126","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1868-4784","authenticated-orcid":true,"given":"Yong-Hyun","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA."},{"name":"Laboratory of Pathology and Physiology, College of Pharmacy, Kangwon National University, Chuncheon 24341, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8802-5346","authenticated-orcid":true,"given":"Emily J.","family":"Onufer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2368-8859","authenticated-orcid":true,"given":"Robert W.","family":"Sprung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-2989","authenticated-orcid":true,"given":"W. 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