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However, whether such pathogen encounters can shape the long-term trajectory of the offspring\u2019s immune system remains unclear. Lim\n                    <jats:italic>et al<\/jats:italic>\n                    . infected pregnant mice with the common food-borne pathogen\n                    <jats:italic>Yersinia pseudotuberculosis<\/jats:italic>\n                    (YopM) (see the Perspective by Amir and Zeng). Although the infection was maternally restricted and short-lived, the offspring harbored greater numbers of intestinal T helper 17 cells into adulthood. Interleukin-6 (IL-6) mediated this tissue-restricted effect by acting on fetal intestinal epithelium during development. Although offspring from mothers infected with YopM or injected with IL-6 showed enhanced resistance to oral infection with\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhimurium, they also exhibited higher susceptibility toward enteric inflammatory disease. \u2014STS\n                  <\/jats:p>","DOI":"10.1126\/science.abf3002","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T15:10:16Z","timestamp":1629990616000},"source":"Crossref","is-referenced-by-count":240,"title":["Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring"],"prefix":"10.1126","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-3136","authenticated-orcid":true,"given":"Ai Ing","family":"Lim","sequence":"first","affiliation":[{"name":"Metaorganism Immunity Section, Laboratory of Immune System Biology and Laboratory of Host Immunity and Microbiome, National Institute of Allergy and 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