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There are efforts toward finding drugs that target viral proteins, but a complementary approach is to target these required host proteins. White\n                    <jats:italic>et al.<\/jats:italic>\n                    explored the antiviral activity of the cyclic depsipeptide drug plitidepsin, which targets the hosts cell's translational machinery (see the Perspective by Wong and Damania). The authors show that in cells, the drug is substantially more potent than remdesivir against SARS-CoV-2, with limited cellular toxicity. Prophylactic treatment protected mice against SARS-CoV-2 infection, so further investigation of plitidepsin as a therapeutic is warranted.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6532\" page=\"926\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.abf4058\">926<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6532\" page=\"884\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126\/science.abg6837\">884<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abf4058","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T15:10:28Z","timestamp":1614265828000},"page":"926-931","source":"Crossref","is-referenced-by-count":324,"title":["Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A"],"prefix":"10.1126","volume":"371","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0889-0506","authenticated-orcid":true,"given":"Kris M.","family":"White","sequence":"first","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA."},{"name":"Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5326-4753","authenticated-orcid":true,"given":"Romel","family":"Rosales","sequence":"additional","affiliation":[{"name":"Department of Microbiology, 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