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In TSC, CLIP cells over-proliferate, generating excessive interneurons, brain tumors, and cortical malformations. Epidermal growth factor receptor inhibition reduces tumor burden, identifying potential treatment options for TSC and related disorders. The identification of CLIP cells reveals the extended interneuron generation in the human brain as a vulnerability for disease. In addition, this work demonstrates that analyzing MCDs can reveal fundamental insights into human-specific aspects of brain development.<\/jats:p>","DOI":"10.1126\/science.abf5546","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T13:57:26Z","timestamp":1643291846000},"source":"Crossref","is-referenced-by-count":156,"title":["Amplification of human interneuron progenitors promotes brain tumors and neurological defects"],"prefix":"10.1126","volume":"375","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-403X","authenticated-orcid":true,"given":"Oliver L.","family":"Eichm\u00fcller","sequence":"first","affiliation":[{"name":"Institute of Molecular Biotechnology (IMBA), Austrian Academy of Sciences, Vienna Biocenter (VBC), Vienna, Austria."},{"name":"University of Heidelberg, Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-3544","authenticated-orcid":true,"given":"Nina 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