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Infants with Down syndrome are often born with a preleukemic condition, which later resolves in most cases. By using gene-edited human cells implanted into mouse models, Wagenblast\n                    <jats:italic>et al.<\/jats:italic>\n                    recapitulated the development of preleukemia and leukemia in the context of Down syndrome (see the Perspective by Roberts and Vyas). A specific mutation triggered a preleukemic condition in the context of trisomy 21 as expected, but progression to full-blown leukemia required a different genetic path and was not dependent on trisomy 21.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , abf6202, this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abf6202\">eabf6202<\/jats:related-article>\n                    ; see also abj3957, p.\n                    <jats:related-article issue=\"6551\" page=\"155\" related-article-type=\"in-this-issue\" vol=\"373\">155<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abf6202","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T04:22:31Z","timestamp":1625804551000},"source":"Crossref","is-referenced-by-count":90,"title":["Mapping the cellular origin and early evolution of leukemia in Down syndrome"],"prefix":"10.1126","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0709-2759","authenticated-orcid":true,"given":"Elvin","family":"Wagenblast","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."},{"name":"Department of Hematology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, 4200-319, Portugal."},{"name":"Faculty of Medicine, University of Porto, Porto, 4200-319, Portugal."},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, University of Porto, Porto, 4200-135, Portugal."},{"name":"Instituto Nacional de Investiga\u00e7\u00e3o Biom\u00e9dica, University of Porto, Porto, 4200-135, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga I.","family":"Gan","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Cutting","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Murison","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Krivdova","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Azkanaz","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"McLeod","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-2433","authenticated-orcid":true,"given":"Blaise A.","family":"Gratton","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-9852","authenticated-orcid":true,"given":"Sajid A.","family":"Marhon","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-4409","authenticated-orcid":true,"given":"Martino","family":"Gabra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-4613","authenticated-orcid":true,"given":"Jessie J. 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