{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:04:50Z","timestamp":1792343090502,"version":"4.4.0"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6569","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,11,12]]},"abstract":"<jats:title>Autoimmunity in Lewy body dementia<\/jats:title>\n                  <jats:p>\n                    Lewy body dementia (LBD) is a brain disease that leads to progressive decline in thinking, movement, and independent function. It results from the build-up of microscopic deposits called Lewy bodies, which develop from the aggregation of a misfolded protein called \u03b1-synuclein. Gate\n                    <jats:italic>et al<\/jats:italic>\n                    . observed immune cells known as T cells in the brains of LBD patients (see the Perspective by Krot and Rolls). Genomics analysis revealed that T cells traffic to the LBD brain and are associated with neuronal damage. When stimulated with \u03b1-synuclein, LBD patient T cells secrete an inflammatory protein known to damage neurons. These findings suggest an unexpected detrimental role of the immune system in LBD. \u2014SMH\n                  <\/jats:p>","DOI":"10.1126\/science.abf7266","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T23:12:48Z","timestamp":1634253168000},"page":"868-874","source":"Crossref","is-referenced-by-count":225,"title":["CD4\n                    <sup>+<\/sup>\n                    T cells contribute to neurodegeneration in Lewy body dementia"],"prefix":"10.1126","volume":"374","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0481-9657","authenticated-orcid":true,"given":"David","family":"Gate","sequence":"first","affiliation":[{"name":"Department of Neurology, Northwestern University, Chicago, IL, USA."},{"name":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA."},{"name":"Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 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