{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:05:17Z","timestamp":1791821117014,"version":"4.3.4"},"reference-count":51,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6553","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:title>Getting around the blood\u2013brain barrier<\/jats:title>\n                  <jats:p>\n                    The meninges comprise three membranes that surround and protect the central nervous system (CNS). Recent studies have noted the existence of myeloid cells resident there, but little is known about their ontogeny and function, and whether other meningeal immune cell populations have important roles remains unclear (see the Perspective by Nguyen and Kubes). Cugurra\n                    <jats:italic>et al.<\/jats:italic>\n                    found in mice that a large proportion of continuously replenished myeloid cells in the dura mater are not blood derived, but rather transit from cranial bone marrow through specialized channels. In models of CNS injury and neuroinflammation, the authors demonstrated that these myeloid cells have an immunoregulatory phenotype compared with their more inflammatory blood-derived counterparts. Similarly, Brioschi\n                    <jats:italic>et al.<\/jats:italic>\n                    show that the meninges host B cells that are also derived from skull bone marrow, mature locally, and likely acquire a tolerogenic phenotype. They further found that the brains of aging mice are infiltrated by a second population of age-associated B cells, which come from the periphery and may differentiate into autoantibody-secreting plasma cells after encountering CNS antigens. Together, these two studies may inform future treatment of neurological diseases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , abf7844, abf9277, this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abf7844\">eabf7844<\/jats:related-article>\n                    , p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abf9277\">eabf9277<\/jats:related-article>\n                    ; see also abj8183, p.\n                    <jats:related-article issue=\"6553\" page=\"396\" related-article-type=\"in-this-issue\" vol=\"373\">396<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abf9277","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T15:17:47Z","timestamp":1622733467000},"source":"Crossref","is-referenced-by-count":461,"title":["Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders"],"prefix":"10.1126","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3849-3926","authenticated-orcid":true,"given":"Simone","family":"Brioschi","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6984-4514","authenticated-orcid":true,"given":"Wei-Le","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, 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