{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:39:45Z","timestamp":1791362385526,"version":"4.3.1"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6543","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005835","name":"American Museum of Natural History","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012292","name":"Gerstner Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,5,14]]},"abstract":"<jats:title>Genomics of radiation-induced damage<\/jats:title>\n                  <jats:p>\n                    The potential adverse effects of exposures to radioactivity from nuclear accidents can include acute consequences such as radiation sickness, as well as long-term sequelae such as increased risk of cancer. There have been a few studies examining transgenerational risks of radiation exposure but the results have been inconclusive. Morton\n                    <jats:italic>et al.<\/jats:italic>\n                    analyzed papillary thyroid tumors, normal thyroid tissue, and blood from hundreds of survivors of the Chernobyl nuclear accident and compared them against those of unexposed patients. The findings offer insight into the process of radiation-induced carcinogenesis and characteristic patterns of DNA damage associated with environmental radiation exposure. In a separate study, Yeager\n                    <jats:italic>et al.<\/jats:italic>\n                    analyzed the genomes of 130 children and parents from families in which one or both parents had experienced gonadal radiation exposure related to the Chernobyl accident and the children were conceived between 1987 and 2002. Reassuringly, the authors did not find an increase in new germline mutations in this population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abg2538\">eabg2538<\/jats:related-article>\n                    , p.\n                    <jats:related-article issue=\"6543\" page=\"725\" related-article-type=\"in-this-issue\" vol=\"372\">725<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abg2365","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T15:15:02Z","timestamp":1619104502000},"page":"725-729","source":"Crossref","is-referenced-by-count":111,"title":["Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl 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