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The lysosomal degradation of integrin \u03b1IIb [ITGA2B (CD41)] carboxyethylated at Cys96 (ITGA2B-ceC96) generated carboxyethylated peptides that were presented by HLA-DRB1*04 to stimulate CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses and induce autoantibody production. Immunization of HLA-DR4 transgenic mice with the ITGA2B-ceC96 peptide promoted colitis and vertebral bone erosion. Thus, metabolite-induced cysteine carboxyethylation can give rise to pathogenic neoantigens that lead to autoreactive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses and autoantibody production in autoimmune diseases.\n                  <\/jats:p>","DOI":"10.1126\/science.abg2482","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T13:58:26Z","timestamp":1678975106000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":89,"title":["Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity"],"prefix":"10.1126","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-7042","authenticated-orcid":true,"given":"Yue","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, 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