{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:54:45Z","timestamp":1793120085887,"version":"4.5.0"},"reference-count":122,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6543","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U24CA082102"],"award-info":[{"award-number":["U24CA082102"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,5,14]]},"abstract":"<jats:title>Genomics of radiation-induced damage<\/jats:title>\n                  <jats:p>\n                    The potential adverse effects of exposures to radioactivity from nuclear accidents can include acute consequences such as radiation sickness, as well as long-term sequelae such as increased risk of cancer. There have been a few studies examining transgenerational risks of radiation exposure but the results have been inconclusive. Morton\n                    <jats:italic>et al.<\/jats:italic>\n                    analyzed papillary thyroid tumors, normal thyroid tissue, and blood from hundreds of survivors of the Chernobyl nuclear accident and compared them against those of unexposed patients. The findings offer insight into the process of radiation-induced carcinogenesis and characteristic patterns of DNA damage associated with environmental radiation exposure. In a separate study, Yeager\n                    <jats:italic>et al.<\/jats:italic>\n                    analyzed the genomes of 130 children and parents from families in which one or both parents had experienced gonadal radiation exposure related to the Chernobyl accident and the children were conceived between 1987 and 2002. Reassuringly, the authors did not find an increase in new germline mutations in this population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.abg2538\">eabg2538<\/jats:related-article>\n                    , p.\n                    <jats:related-article issue=\"6543\" page=\"725\" related-article-type=\"in-this-issue\" vol=\"372\">725<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abg2538","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T15:14:18Z","timestamp":1619104458000},"source":"Crossref","is-referenced-by-count":172,"title":["Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident"],"prefix":"10.1126","volume":"372","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-2310","authenticated-orcid":true,"given":"Lindsay M.","family":"Morton","sequence":"first","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-5625","authenticated-orcid":true,"given":"Danielle M.","family":"Karyadi","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2245-9552","authenticated-orcid":true,"given":"Chip","family":"Stewart","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-0236","authenticated-orcid":true,"given":"Tetiana I.","family":"Bogdanova","sequence":"additional","affiliation":[{"name":"Laboratory of Morphology of the Endocrine System, V. 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Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-1653","authenticated-orcid":true,"given":"Eric T.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA."},{"name":"Nvidia Corporation, Santa Clara, CA 95051, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7642-5265","authenticated-orcid":true,"given":"Mia K.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, 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