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In some taxa, this process occurs often. The XY system in mammals, however, has been evolutionarily stable across a wide array of species. Fifty years ago, a variation on this norm was described in the creeping vole (\n                    <jats:italic>Microtus oregoni<\/jats:italic>\n                    ), but the details have remained mostly unknown. Couger\n                    <jats:italic>et al.<\/jats:italic>\n                    sequenced the sex chromosomes in this species and found that the Y chromosome has been lost, the male-determining chromosome is a second X that is largely homologous to the female X, and both the maternally inherited and male-specific sex chromosomes carry vestiges of the ancestral Y.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article issue=\"6542\" page=\"592\" related-article-type=\"in-this-issue\" vol=\"372\">592<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abg7019","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T15:11:28Z","timestamp":1620313888000},"page":"592-600","source":"Crossref","is-referenced-by-count":28,"title":["Sex chromosome transformation and the origin of a male-specific X 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