{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:26:29Z","timestamp":1790205989108,"version":"4.1.0"},"reference-count":111,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6599","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2022,6,17]]},"abstract":"<jats:p>A hallmark of meiosis is chromosomal pairing, which requires telomere tethering and rotation on the nuclear envelope through microtubules, driving chromosome homology searches. Telomere pulling toward the centrosome forms the \u201czygotene chromosomal bouquet.\u201d Here, we identified the \u201czygotene cilium\u201d in oocytes. This cilium provides a cable system for the bouquet machinery and extends throughout the germline cyst. Using zebrafish mutants and live manipulations, we demonstrate that the cilium anchors the centrosome to counterbalance telomere pulling. The cilium is essential for bouquet and synaptonemal complex formation, oogenesis, ovarian development, and fertility. Thus, a cilium represents a conserved player in zebrafish and mouse meiosis, which sheds light on reproductive aspects in ciliopathies and suggests that cilia can control chromosomal dynamics.<\/jats:p>","DOI":"10.1126\/science.abh3104","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T14:00:30Z","timestamp":1652364030000},"source":"Crossref","is-referenced-by-count":62,"title":["Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium"],"prefix":"10.1126","volume":"376","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-8614","authenticated-orcid":true,"given":"Avishag","family":"Mytlis","sequence":"first","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2034-7645","authenticated-orcid":true,"given":"Vineet","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2291-8053","authenticated-orcid":true,"given":"Tao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, Proteos 138673, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Deis","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neta","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-5830","authenticated-orcid":true,"given":"Markus","family":"Masek","sequence":"additional","affiliation":[{"name":"Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland."},{"name":"Institute of Medical Genetics, University of Zurich, 8952 Schlieren, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Shawahny","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-2638","authenticated-orcid":true,"given":"Hagai","family":"Eitan","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farouq","family":"Nather","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-8341","authenticated-orcid":true,"given":"Shai","family":"Adar-Levor","sequence":"additional","affiliation":[{"name":"Departments of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3792-1095","authenticated-orcid":true,"given":"Ramon Y.","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Departments of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-6173","authenticated-orcid":true,"given":"Natalie","family":"Elia","sequence":"additional","affiliation":[{"name":"Departments of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-5271","authenticated-orcid":true,"given":"Ruxandra","family":"Bachmann-Gagescu","sequence":"additional","affiliation":[{"name":"Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland."},{"name":"Institute of Medical Genetics, University of Zurich, 8952 Schlieren, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-1429","authenticated-orcid":true,"given":"Sudipto","family":"Roy","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, Proteos 138673, Singapore."},{"name":"Department of Biological Sciences, National University of Singapore, 117543 Singapore."},{"name":"Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 119288 Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9043-4106","authenticated-orcid":true,"given":"Yaniv M.","family":"Elkouby","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, Hebrew University of Jerusalem Faculty of Medicine, Ein-Kerem Campus, Jerusalem 9112102, Israel."},{"name":"Institute for Medical Research-Israel-Canada (IMRIC), Ein-Kerem Campus, Jerusalem 9112102, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.02.018"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.05.006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.114.165290"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702312114"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08287"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21455"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414814112"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3208"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.048"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.03.018"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201304004"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201204085"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.10.039"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.030"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2896"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.1.95"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004821"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002335"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/35085086"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.06.029"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007730"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24166"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.12.014"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.73"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20170453"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.036350"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3451"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110778"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028076"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.02.025"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.4161\/cib.13550"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2016.03.032"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213960"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.09.058"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002416"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1086\/519494"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21337"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20614"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1805"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003955"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/hgv.2015.6"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2988"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.826"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr332"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.891"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.01.016"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001034"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22661"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247671"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406212102"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02166"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl107"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1786"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.07.004"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e12-02-0134"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015800"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2345"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03633-5"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.040705.141236"},{"key":"e_1_3_3_62_2","doi-asserted-by":"crossref","unstructured":"P. P. D\u2019Gama T. Qiu M. I. Cosacak D. Rayamajhi A. Konac J. N. Hansen C. Ringers F. Acu\u00f1a-Hinrichsen S. P. Hui E. W. Olstad Y. L. Chong C. K. A. Lim A. Gupta C. P. Ng B. S. Nilges N. D. Kashikar D. Wachten D. Liebl K. Kikuchi C. Kizil E. Yaksi S. Roy N. Jurisch-Yaksi Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Cell Rep. 37 109775 (2021). 10.1101\/2021.02.17.431442","DOI":"10.1016\/j.celrep.2021.109775"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1673-8527(08)60150-2"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2277"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006993"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI131656"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.07.005"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0054-7"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.05.010"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox096"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.10.045"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5316.1252"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3496"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3493"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.189910"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.2.10691"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006704"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz1139"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.05.024"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07794-7"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08437-1"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.061"},{"key":"e_1_3_3_83_2","doi-asserted-by":"crossref","unstructured":"E. J. Navarro W. F. Marshall J. C. Fung Modeling cell biological features of meiotic chromosome pairing. bioRxiv 475288 [Preprint] (2022); .10.1101\/2022.01.06.475288","DOI":"10.1101\/2022.01.06.475288"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0209-6"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.162628"},{"key":"e_1_3_3_86_2","doi-asserted-by":"crossref","unstructured":"S. Zahid K. Branham D. Schlegel M. E. Pennesi M. Michaelides J. Heckenlively T. Jayasundera \u201c CEP290 \u201d in Retinal Dystrophy Gene Atlas (Springer 2018) pp. 47\u201349.","DOI":"10.1007\/978-3-319-10867-4_15"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2010.05.009"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.115"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00244"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70136-4"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22113"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406252102"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2042"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-001-0196-x"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.130065"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2021210118"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.4.875"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2016.09.016"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.076299"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.167023"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.05.557"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.093864"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22404"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(99)01594-9"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2017.09.001"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-11-0299"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1052180209"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2156"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020911-153342"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.03.004"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2505"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040701"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1095-8649.2003.00074.x"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.abh3104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T18:45:04Z","timestamp":1705344304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.abh3104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,17]]},"references-count":111,"journal-issue":{"issue":"6599","published-print":{"date-parts":[[2022,6,17]]}},"alternative-id":["10.1126\/science.abh3104"],"URL":"https:\/\/doi.org\/10.1126\/science.abh3104","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,17]]},"article-number":"eabh3104"}}