{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:16:46Z","timestamp":1788477406875,"version":"build-2803163510"},"reference-count":51,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6581","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2022,2,11]]},"abstract":"<jats:p>\n                    Dendritic cells (DCs) are crucial for initiating adaptive immune responses. However, the factors that control DC positioning and homeostasis are incompletely understood. We found that type-2 conventional DCs (cDC2s) in the spleen depend on G\u03b1\n                    <jats:sub>13<\/jats:sub>\n                    and adhesion G protein\u2013coupled receptor family member-E5 (Adgre5, or CD97) for positioning in blood-exposed locations. CD97 function required its autoproteolytic cleavage. CD55 is a CD97 ligand, and cDC2 interaction with CD55-expressing red blood cells (RBCs) under shear stress conditions caused extraction of the regulatory CD97 N-terminal fragment. Deficiency in CD55-CD97 signaling led to loss of splenic cDC2s into the circulation and defective lymphocyte responses to blood-borne antigens. Thus, CD97 mechanosensing of RBCs establishes a migration and gene expression program that optimizes the antigen capture and presentation functions of splenic cDC2s.\n                  <\/jats:p>","DOI":"10.1126\/science.abi5965","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T14:03:22Z","timestamp":1644501802000},"source":"Crossref","is-referenced-by-count":84,"title":["CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells"],"prefix":"10.1126","volume":"375","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5601-8053","authenticated-orcid":true,"given":"Dan","family":"Liu","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Duan","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-8166","authenticated-orcid":true,"given":"Lauren B.","family":"Rodda","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-5146","authenticated-orcid":true,"given":"Erick","family":"Lu","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"An","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-0608","authenticated-orcid":true,"given":"Fengchun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0241-9190","authenticated-orcid":true,"given":"Mark R.","family":"Looney","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0589-6224","authenticated-orcid":true,"given":"Zhiyong","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA."},{"name":"Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1879-9047","authenticated-orcid":true,"given":"Christopher D. C.","family":"Allen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA."},{"name":"Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmei","family":"Li","sequence":"additional","affiliation":[{"name":"J. David Gladstone Institutes, San Francisco, CA 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-5776","authenticated-orcid":true,"given":"Alexander","family":"Marson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"J. David Gladstone Institutes, San Francisco, CA 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4735-9745","authenticated-orcid":true,"given":"Jason G.","family":"Cyster","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA."},{"name":"Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0088-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00413-x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1669"},{"key":"e_1_3_3_5_2","first-page":"455","article-title":"Arterial terminals in the rat spleen as demonstrated by scanning electron microscopy of vascular casts","volume":"1982","author":"Yamamoto K.","year":"1982","unstructured":"K. Yamamoto, T. Kobayashi, T. Murakami, Arterial terminals in the rat spleen as demonstrated by scanning electron microscopy of vascular casts. Scan. Electron Microsc. 1982, 455\u2013458 (1982). 7167761","journal-title":"Scan. Electron Microsc."},{"key":"e_1_3_3_6_2","first-page":"613","article-title":"Comparative aspects of splenic microcirculatory pathways in mammals: The region bordering the white pulp","volume":"7","author":"Schmidt E. E.","year":"1993","unstructured":"E. E. Schmidt, I. C. MacDonald, A. C. Groom, Comparative aspects of splenic microcirculatory pathways in mammals: The region bordering the white pulp. Scanning Microsc. 7, 613\u2013628 (1993). 8108677","journal-title":"Scanning Microsc."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00757"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.076"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aal5237"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20192300"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11738"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2555"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.08.002"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12743"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.013"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003825"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010617-052933"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV120.007423"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.1125"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e11"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.1185"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.071"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13027"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.11.036"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai7677"},{"key":"e_1_3_3_26_2","unstructured":"E. S. Russell S. E. Bernstein in Biology of the Laboratory Mouse E. L. Green Ed. (Dover Publications 1966) vol. 2 chap. 17."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202192"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2006.09.008"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.218222"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01138"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-595603"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164206"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051269"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1809925115"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02481.x"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.009"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17947"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.02.007"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102613"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.028"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.017"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam9169"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-41523-9_10"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5251.981"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2008921117"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1164"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503326102"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.733154"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7474-0_3"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.5.1324.1324"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.3791\/59616"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.abi5965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T18:03:45Z","timestamp":1705341825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.abi5965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,11]]},"references-count":51,"journal-issue":{"issue":"6581","published-print":{"date-parts":[[2022,2,11]]}},"alternative-id":["10.1126\/science.abi5965"],"URL":"https:\/\/doi.org\/10.1126\/science.abi5965","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.741605916.793592622","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,11]]},"article-number":"eabi5965"}}