{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:16:17Z","timestamp":1791958577746,"version":"4.3.4"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6560","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,9,10]]},"abstract":"<jats:title>Prevention of compulsive cocaine taking<\/jats:title>\n                  <jats:p>\n                    Over time, about 20% of chronic cocaine users lose control and become addicted. There are indications that the differential efficacy of the brain serotonin (5-HT) system may be involved in the vulnerability to drug addiction. However, the relevant circuits and underlying cellular processes remain elusive. Li\n                    <jats:italic>et al<\/jats:italic>\n                    . discovered a synaptic mechanism in mice that underlies the modulatory role of 5-HT in reducing the likelihood of transition to compulsion and eventually addiction (see the Perspective by Miyazaki and Miyazaki). Cocaine binds to 5-HT transporters to block 5-HT reuptake. The elevated extracellular 5-HT activates 5-HT\n                    <jats:sub>1B<\/jats:sub>\n                    receptors and causes presynaptic depression of a projection from the orbitofrontal cortex to the dorsal striatum. These changes reduce the likelihood of inducing postsynaptic potentiation at these synapses, which ultimately drives compulsion. \u2014PRS\n                  <\/jats:p>","DOI":"10.1126\/science.abi9086","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T13:58:32Z","timestamp":1631195912000},"page":"1252-1256","source":"Crossref","is-referenced-by-count":107,"title":["Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction"],"prefix":"10.1126","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-6144","authenticated-orcid":true,"given":"Yue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland."},{"name":"IDG McGovern Institute for Brain Research, Peking University, Beijing 100871, 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