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Holden\n                    <jats:italic>et al<\/jats:italic>\n                    . found that secondary and chronic neuroinflammation and neurodegeneration are caused by the C1q molecule, a mediator of the complement pathway. C1q is responsible for chronic inflammation and secondary neuronal loss specifically in the cortico-thalamo-cortical circuit. Traumatic brain injury also leads to altered brain states that are caused by the C1q complement pathway. \u2014PRS\n                  <\/jats:p>","DOI":"10.1126\/science.abj2685","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T13:58:32Z","timestamp":1631195912000},"source":"Crossref","is-referenced-by-count":135,"title":["Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury"],"prefix":"10.1126","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0513-5444","authenticated-orcid":true,"given":"Stephanie S.","family":"Holden","sequence":"first","affiliation":[{"name":"Neurosciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA."},{"name":"Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA."},{"name":"Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, 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