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The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.<\/jats:p>","DOI":"10.1126\/science.abj5861","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T13:59:54Z","timestamp":1646920794000},"source":"Crossref","is-referenced-by-count":387,"title":["Local connectivity and synaptic dynamics in mouse and human neocortex"],"prefix":"10.1126","volume":"375","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2959-1284","authenticated-orcid":true,"given":"Luke","family":"Campagnola","sequence":"first","affiliation":[{"name":"Allen Institute for Brain Science, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-1992","authenticated-orcid":true,"given":"Stephanie C.","family":"Seeman","sequence":"additional","affiliation":[{"name":"Allen Institute for Brain Science, Seattle, WA, 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